Digestive Diseases and Sciences

, Volume 38, Issue 9, pp 1590–1595

Terminal ileal mucosal mast cells in irritable bowel syndrome

Authors

  • Allan P. Weston
    • Department of Medicine 4035 DelpUniversity of Kansas Hospital
  • Wendy L. Biddle
    • Department of Medicine 4035 DelpUniversity of Kansas Hospital
  • Paramjit S. Bhatia
    • Department of Medicine 4035 DelpUniversity of Kansas Hospital
  • Philip B. MinerJr
    • Department of Medicine 4035 DelpUniversity of Kansas Hospital
Original Articles

DOI: 10.1007/BF01303164

Cite this article as:
Weston, A.P., Biddle, W.L., Bhatia, P.S. et al. Digest Dis Sci (1993) 38: 1590. doi:10.1007/BF01303164

Abstract

Terminal ileal biopsies were prospectively obtained and stained specifically for mast cells in 20 patients with irritable bowel syndrome (IBS) and 15 controls. The number of terminal ileal mast cells per high powered field (MC/HPF) (mean ±SEM) was 23.3±3.1 for, IBS and 6.8±1.1 for controls (P=0.0001). The diarrhea IBS subgroup had the greatest number of MC/HPF. No correlation was found between terminal ileal mucosal mast cell counts (MMCC) and the number of Manning criteria present or the functional bowel disease score (r=0.06 andr=−0.31, respectively). We conclude that terminal ileal MMCC are significantly elevated in a majority of patients with IBS. The mast cell may be responsible for the altered visceral perception found in the gastrointestinal tract in patients with IBS. The poor correlation of the MMCC to the clinical features of IBS may be the result of the dynamic state of the mast cell.

Key Words

afferent neuronsfunctional bowel diseaseileoscopyvisceral perception

Copyright information

© Plenum Publishing Corporation 1993