Original Articles

Digestive Diseases and Sciences

, Volume 38, Issue 12, pp 2151-2155

Prevalence of hepatitis C virus infection in asymptomatic anti-HIV1 negative pregnant women and their children

  • Patrick MarcellinAffiliated withService d'Hépatologie and Unité de Recherches de Physiopathologie Hépatique (INSERM), Hôpital BeaujonService d'Hématologie et d'Immunologie, Laboratoire de Biochimie, Hôpital BeaujonService de Gynécologie et Obstétrique, Hôpital BeaujonMolecular Biology Department, EIBETOrtho Diagnostic Systems
  • , Jacques BernuauAffiliated withService d'Hépatologie and Unité de Recherches de Physiopathologie Hépatique (INSERM), Hôpital BeaujonService d'Hématologie et d'Immunologie, Laboratoire de Biochimie, Hôpital BeaujonService de Gynécologie et Obstétrique, Hôpital BeaujonMolecular Biology Department, EIBETOrtho Diagnostic Systems
  • , Michèle Martinot-PeignouxAffiliated withService d'Hépatologie and Unité de Recherches de Physiopathologie Hépatique (INSERM), Hôpital BeaujonService d'Hématologie et d'Immunologie, Laboratoire de Biochimie, Hôpital BeaujonService de Gynécologie et Obstétrique, Hôpital BeaujonMolecular Biology Department, EIBETOrtho Diagnostic Systems
  • , Daniel LarzulAffiliated withService d'Hépatologie and Unité de Recherches de Physiopathologie Hépatique (INSERM), Hôpital BeaujonService d'Hématologie et d'Immunologie, Laboratoire de Biochimie, Hôpital BeaujonService de Gynécologie et Obstétrique, Hôpital BeaujonMolecular Biology Department, EIBETOrtho Diagnostic Systems
  • , Li-Zhe XuAffiliated withService d'Hépatologie and Unité de Recherches de Physiopathologie Hépatique (INSERM), Hôpital BeaujonService d'Hématologie et d'Immunologie, Laboratoire de Biochimie, Hôpital BeaujonService de Gynécologie et Obstétrique, Hôpital BeaujonMolecular Biology Department, EIBETOrtho Diagnostic Systems
  • , Sebastien TranAffiliated withService d'Hépatologie and Unité de Recherches de Physiopathologie Hépatique (INSERM), Hôpital BeaujonService d'Hématologie et d'Immunologie, Laboratoire de Biochimie, Hôpital BeaujonService de Gynécologie et Obstétrique, Hôpital BeaujonMolecular Biology Department, EIBETOrtho Diagnostic Systems
  • , Annie BezeaudAffiliated withService d'Hépatologie and Unité de Recherches de Physiopathologie Hépatique (INSERM), Hôpital BeaujonService d'Hématologie et d'Immunologie, Laboratoire de Biochimie, Hôpital BeaujonService de Gynécologie et Obstétrique, Hôpital BeaujonMolecular Biology Department, EIBETOrtho Diagnostic Systems
  • , Marie-Christine GuimontAffiliated withService d'Hépatologie and Unité de Recherches de Physiopathologie Hépatique (INSERM), Hôpital BeaujonService d'Hématologie et d'Immunologie, Laboratoire de Biochimie, Hôpital BeaujonService de Gynécologie et Obstétrique, Hôpital BeaujonMolecular Biology Department, EIBETOrtho Diagnostic Systems
  • , Michel LevardonAffiliated withService d'Hépatologie and Unité de Recherches de Physiopathologie Hépatique (INSERM), Hôpital BeaujonService d'Hématologie et d'Immunologie, Laboratoire de Biochimie, Hôpital BeaujonService de Gynécologie et Obstétrique, Hôpital BeaujonMolecular Biology Department, EIBETOrtho Diagnostic Systems
    • , Pascale AumontAffiliated withService d'Hépatologie and Unité de Recherches de Physiopathologie Hépatique (INSERM), Hôpital BeaujonService d'Hématologie et d'Immunologie, Laboratoire de Biochimie, Hôpital BeaujonService de Gynécologie et Obstétrique, Hôpital BeaujonMolecular Biology Department, EIBETOrtho Diagnostic Systems
    • , Serge ErlingerAffiliated withService d'Hépatologie and Unité de Recherches de Physiopathologie Hépatique (INSERM), Hôpital BeaujonService d'Hématologie et d'Immunologie, Laboratoire de Biochimie, Hôpital BeaujonService de Gynécologie et Obstétrique, Hôpital BeaujonMolecular Biology Department, EIBETOrtho Diagnostic Systems
    • , Jean-Pierre BenhamouAffiliated withService d'Hépatologie and Unité de Recherches de Physiopathologie Hépatique (INSERM), Hôpital BeaujonService d'Hématologie et d'Immunologie, Laboratoire de Biochimie, Hôpital BeaujonService de Gynécologie et Obstétrique, Hôpital BeaujonMolecular Biology Department, EIBETOrtho Diagnostic Systems

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

The prevalence of hepatitis C virus (HCV) infection was studied prospectively in pregnant women in France and their children by detection of anti-HCV with second-generation ELISA (ELISA2). In ELISA2-positive women, anti-HCV was detected with second- and third-generation RIBA (RIBA2 and RIBA3) and serum HCV RNA was detected with PCR. Among 670 women, anti-HIV1-negative, 26 (3.9%) were positive with ELISA2. RIBA2 was positive in 13 and HCV RNA was found in 10. Ten ELISA2-positive women had a further evaluation with assessment of HCV infection in their children. Among the 10 children born to the index pregnancy, only one was positive with ELISA2 and RIBA2 but negative with RIBA3 and PCR; the nine other children were ELISA2, RIBA2, RIBA3, and PCR negative. All 26 siblings (2–16 years old), of whom 14 were born to PCR-positive mothers, were ELISA2 and RIBA2 negative. We conclude that among anti-HIV1-negative pregnant women with normal serum ALT levels, the prevalence of HCV infection is relatively high but the risk for mother-to-infant transmission of HCV seems to be low.

Key Words

anti-HCV hepatitis C virus polymerase chain reaction mother-to-infant transmission epidemiology