Original Articles

Digestive Diseases and Sciences

, Volume 27, Issue 3, pp 217-219

Cimetidine in the management of symptomatic patients with duodenitis

A double-blind controlled trial
  • M. MackinnonAffiliated withDepartment of Medicine, Flinders Medical CentreDepartment of Histopathology, Flinders Medical Centre
  • , R. L. WillingAffiliated withDepartment of Medicine, Flinders Medical CentreDepartment of Histopathology, Flinders Medical Centre
  • , R. WhiteheadAffiliated withDepartment of Medicine, Flinders Medical CentreDepartment of Histopathology, Flinders Medical Centre

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Abstract

Twenty-one adult outpatients with dyspepsia and endoscopically proven duodenitis without chronic ulceration completed a double-blind trial of either cimetidine (1 g/day) or placebo. Treatment with cimetidine for 6 weeks resulted in a significant improvement in symptoms and in the endoscopic appearance of the duodenitis when compared to treatment with placebo. The symptomatic and endoscopic inprovement, however, was not associated with any significant change in the histological grading of the duodenitis.