Archiv für die gesamte Virusforschung

, Volume 31, Issue 3, pp 191-195

First online:

Effect of statolon on lactate dehydrogenase virus infection in mice

  • Charles G. CrispensJr.Affiliated withDepartment of Anatomy, University of Sherbrooke Faculty of Medicine

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Statolon, an interferon inducer, was found to be effective in inhibiting the multiplication of the lactate dehydrogenase (LDH) virus in mice. Under the conditions tested, optimal protection was achieved by a single intraperitoneal injection (4.5 mg/20 to 22 g mouse) given 6 to 12 hours prior to the challenge. When various dilutions of the virus were compared, a relationship was observed between the original dose and the loss in titer at 24 hours. The results are interpreted as evidence supporting the view that interferon plays a role in the abrupt suppression of the initial high rate of LDH virus replication.