Journal of Neural Transmission

, Volume 70, Issue 3, pp 377–381

Increasedα 2;-adrenoceptor density in the frontal cortex of depressed suicide victims

Authors

  • J. J. Meana
    • Department of Pharmacology, Faculty of MedicineUniversity of the Basque Country
  • J. A. García-Sevilla
    • Department of Pharmacology, Faculty of MedicineUniversity of the Basque Country
Short Note

DOI: 10.1007/BF01253612

Cite this article as:
Meana, J.J. & García-Sevilla, J.A. J. Neural Transmission (1987) 70: 377. doi:10.1007/BF01253612

Summary

The density of brainα 2-adrenoceptors, quantitated by means of the binding of the agonist [3H]clonidine, was studied in post-mortem cortical membranes of matched control subjects and depressed suicide victims. In the depressed suicide group, the specific high affinity binding of [3H]clonidine was found to be significantly increased (Bmax, 72% greater; p<0.01) without significant changes in the KD value for the radioligand. These preliminary results indicate thatα 2-adrenoceptor density in the high affinity stateα 2H) is increased in the brain of depressed patients and add strong support to the hypothesis that endogenous depression is related to supersensitiveα 2-adrenoceptors.

Key words

α 2-Adrenoceptors human brain suicide depression

Copyright information

© Springer-Verlag 1987