Summary
Heat- and acid-treatments of EG-NDV, which was essentially a very poor inducer of interferon in PCE cells, resulted in the development of the potency to stimulate interferon synthesis. Optimum temperature to bring about the activation was 56° C, and the peak of the potency was obtained after 4–6 minutes. Effective pH range was 1.6–2.5. Neutral and alkaline pH did not exhibit the stimulatory effect. A hypothetical mechanism to interprete the observed facts is presented, which assumes a heat- and acid-labile component in the virion inhibitory to the induction or synthesis of interferon in PCE cells.
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Kohno, S., Kohase, M. & Shimizu, Y. Studies on interferon induction by Newcastle disease virus (NDV). Archiv f Virusforschung 28, 188–196 (1969). https://doi.org/10.1007/BF01249383
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DOI: https://doi.org/10.1007/BF01249383