Journal of Neural Transmission / General Section JNT

, Volume 85, Issue 3, pp 181–194

Serotonergic measures in suicide brain: 5-HT1A binding sites in frontal cortex of suicide victims

Authors

  • S. Matsubara
    • Department of PsychiatryHokkaido University School of Medicine
  • R. C. Arora
    • Laboratory of Biological Psychiatry, Department of PsychiatryCase Western Reserve University, School of Medicine
  • H. Y. Meltzer
    • Laboratory of Biological Psychiatry, Department of PsychiatryCase Western Reserve University, School of Medicine
Full Papers

DOI: 10.1007/BF01244944

Cite this article as:
Matsubara, S., Arora, R.C. & Meltzer, H.Y. J. Neural Transmission (1991) 85: 181. doi:10.1007/BF01244944

Summary

The density of 5-HT1A binding using3H-8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) as binding ligand, was studied in human frontal cortex of suicide victims and normal controls who died due to medical disease or accidentally. There was no difference in the maximum number of binding site (Bmax) or Kd (an inverse measure of affinity) of 5-HT1A receptor binding sites between normal controls and the entire group of suicide victims. However, nonviolent suicides had significantly higher Bmax (22—25%) compared to both controls and violent suicides. A negative correlation between age and Bmax of 5-HT1A binding sites was found in male controls but not in female controls or suicide victims. This relationship was less apparent among the male controls over age 60.

Keywords

Serotonin1A (5-HT1A) receptorbrainsuicide

Copyright information

© Springer-Verlag 1991