Journal of Neural Transmission / General Section JNT

, Volume 93, Issue 1, pp 67–70

Sexual differences in sensitivity to methamphetamine toxicity


  • G. C. Wagner
    • Department of PsychologyRutgers University
  • T. L. Tekirian
    • Department of PsychologyRutgers University
  • C. T. Cheo
    • Department of PsychologyRutgers University
Short Communication

DOI: 10.1007/BF01244939

Cite this article as:
Wagner, G.C., Tekirian, T.L. & Cheo, C.T. J. Neural Transmission (1993) 93: 67. doi:10.1007/BF01244939


Male and female mice were treated with methamphetamine (10.0 mg/kg/injection for four injections) and sacrificed two weeks later. It was observed that the methamphetamine treatment caused depletions in striatal dopamine which were significantly greater in males (74%) than in females (56%). These results indicate that estrogen may have a protective effect against methamphetamine-induced dopamine depletions and may relate to the fact that males are more likely to incur Parkinson's disease than females.


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© Springer-Verlag 1993