Journal of Neural Transmission / General Section JNT

, Volume 93, Issue 1, pp 67–70

Sexual differences in sensitivity to methamphetamine toxicity

  • G. C. Wagner
  • T. L. Tekirian
  • C. T. Cheo
Short Communication

DOI: 10.1007/BF01244939

Cite this article as:
Wagner, G.C., Tekirian, T.L. & Cheo, C.T. J. Neural Transmission (1993) 93: 67. doi:10.1007/BF01244939

Summary

Male and female mice were treated with methamphetamine (10.0 mg/kg/injection for four injections) and sacrificed two weeks later. It was observed that the methamphetamine treatment caused depletions in striatal dopamine which were significantly greater in males (74%) than in females (56%). These results indicate that estrogen may have a protective effect against methamphetamine-induced dopamine depletions and may relate to the fact that males are more likely to incur Parkinson's disease than females.

Keywords

MethamphetamineParkinson'ssexdopamine

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • G. C. Wagner
    • 1
  • T. L. Tekirian
    • 1
  • C. T. Cheo
    • 1
  1. 1.Department of PsychologyRutgers UniversityNew BrunswickUSA