Short Communication

Journal of Neural Transmission / General Section JNT

, Volume 93, Issue 1, pp 67-70

First online:

Sexual differences in sensitivity to methamphetamine toxicity

  • G. C. WagnerAffiliated withDepartment of Psychology, Rutgers University
  • , T. L. TekirianAffiliated withDepartment of Psychology, Rutgers University
  • , C. T. CheoAffiliated withDepartment of Psychology, Rutgers University

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Male and female mice were treated with methamphetamine (10.0 mg/kg/injection for four injections) and sacrificed two weeks later. It was observed that the methamphetamine treatment caused depletions in striatal dopamine which were significantly greater in males (74%) than in females (56%). These results indicate that estrogen may have a protective effect against methamphetamine-induced dopamine depletions and may relate to the fact that males are more likely to incur Parkinson's disease than females.


Methamphetamine Parkinson's sex dopamine