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Pharmacological blood-brain barrier modification for selective drug delivery

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Abstract

Vasoactive agents have been identified through studies of peritumoral edema and effects on systemic capillaries. Abnormal blood-brain barrier or blood-tumor barrier can develop transient increases in permeability with the intraarterial delivery of vasoactive agents. Normal blood-brain barrier resists the effects of these compounds because of a biochemical barrier that may inactivate or become inert to vasoactive agents. Vaso-active compounds, including leukotrienes, bradykinin, and histamine appear to selectively increase permeability in abnormal brain capillaries. Intracarotid infusion of leukotrienes, bradykinin, and other vasoactive agents can increase drug delivery to diseased tissue.

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Authors and Affiliations

  1. UCLA Department of Neurology, Jonsson Cancer Center, UCLA Neuro-Oncology Program, UCLA School of Medicine, USA

    Timothy F. Cloughesy

  2. UCLA Division of Neurosurgery, Jonsson Cancer Center, UCLA Neuro-Oncology Program, UCLA School of Medicine, USA

    Keith L. Black

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  1. Timothy F. Cloughesy
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  2. Keith L. Black
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Cloughesy, T.F., Black, K.L. Pharmacological blood-brain barrier modification for selective drug delivery. J Neuro-Oncol 26, 125–132 (1995). https://doi.org/10.1007/BF01060218

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