Effect of altered urinarypH on tetracycline and doxycycline excretion in humans
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The effect of altered urinary pH on the excretion of single doses of orally administered tetracycline hydrochloride and doxycycline hyclate was studied in humans. Alkalinization of the urine significantly enhanced the cumulative renal excretion of both tetracycline and doxycycline as compared to acidic urine treatments. Altered tubular reabsorption was assumed to have caused this effect, since tetracyclines have been shown to be more lipid soluble at their isoelectric pH (approximately the pH of the acidic urine treatment) as compared to more alkaline pHs. The renal clearance of doxycycline was significantly increased by urinary alkalinization.
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- Effect of altered urinarypH on tetracycline and doxycycline excretion in humans
Journal of Pharmacokinetics and Biopharmaceutics
Volume 1, Issue 4 , pp 267-282
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers-Plenum Publishers
- Additional Links
- tetracycline hydrochloride
- doxycycline hyclate
- Industry Sectors
- Author Affiliations
- 1. Department of Pharmaceutics, School of Pharmacy, University of Pittsburgh, 15261, Pittsburgh, Pennsylvania
- 2. Department of Medicine, School of Medicine, University of Pittsburgh, 15261, Pittsburgh, Pennsylvania