Abstract
A set of 18 synthetic uniform overlapping peptides spanning the entire extracellular part (residues 1–210) of the α-subunit of human acetylcholine receptor were studied for their binding activity of125I-labeled α-bungarotoxin and cobratoxin. A major toxin-binding region was found to reside within peptide α122–138. In addition, low-binding activities were obtained with peptides α34–49 and α194–210. It is concluded that the region within residues α122–138 constitutes a universal major toxin-binding region for acetylcholine receptor of various species.
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Mulac-Jericevic, B., Manshouri, T., Yokoi, T. et al. The regions of α-neurotoxin binding on the extracellular part of the α-subunit of human acetylcholine receptor. J Protein Chem 7, 173–177 (1988). https://doi.org/10.1007/BF01025247
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DOI: https://doi.org/10.1007/BF01025247