European Journal of Clinical Pharmacology

, Volume 31, Issue 3, pp 277-280

First online:

Treatment of chronic urticaria with terfenadine and ranitidine

A randomized double-blind study in 45 patients
  • E. PaulAffiliated withZentrum für Dermatologie und Andrologie (Hautklinik), Justus Liebig-Universität Giessen
  • , R. H. BödekerAffiliated withInstitut für Medizinische Informatik, Justus Liebig-Universität Giessen

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45 patients with chronic urticaria were randomized to double blind therapy with terfenadine an H1-antihistamine or ranitidine, an H2-antihistamine, or a combination of both drugs. The therapeutic response was assessed by diary scores. The primary effect variable was “itching”. The inference-statistical evaluation of the patient scores showed varying therapeutic effects. The Type-I error wasp=0.015. Itching was reported to be significantly lower by patients receiving both drugs than by those who were given terfenadine alone, while ranitidine in monotherapy had no significant effect on itching. A similar trend was seen in assessment of the severity of weals, while the treatment regimens had no influence on swelling.

Key words

urticaria terfenadine ranitidine randomized double-blind study therapeutic response