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Do circulating factors play a role in the pathogenesis of minimal change nephrotic syndrome?

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Abstract

This review examines the studies which have been undertaken to test the hypothesis that minimal change nephrotic syndrome of childhood (MCNS) is a primary immune disorder and that there is altered T-cell function which results in release of a circulating factor. This factor alters glomerular permeability, perhaps by modifying charge sites in the glomerular capillary bed, and results in selective proteinuria. The abnormalities in immune function observed in MCNS are summarized, as are the studies of circulating factors which have been identified. Although some agents have been shown to alter capillary permeability, the unequivocal demonstration of such a factor causing selective proteinuria in vivo, either directly or indirectly, is lacking. The question is raised whether intrarenal release or activation of mediators of altered permeability, rather than the systemic release of such factors, may be important in the pathogenesis of MCNS.

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  1. Department of Pathology, University Hospital of Groningen, Oostersingel 63, NL-9713 EZ, Groningen, The Netherlands

    Winston W. Bakker

  2. Department of Paediatrics, University Hospital of Groningen, Oostersingel 63, NL-9713 EZ, Groningen, The Netherlands

    Wilma H. J. van Luijk

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Bakker, W.W., van Luijk, W.H.J. Do circulating factors play a role in the pathogenesis of minimal change nephrotic syndrome?. Pediatr Nephrol 3, 341–349 (1989). https://doi.org/10.1007/BF00858545

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