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Solid-state, optical-rotation measurements on macromolecules using powder-suspensions

Messung der optischen Rotation von Makromolekülen im Festzustand unter Verwendung von Pulversuspensionen

  • Organische Chemie Und Biochemie
  • Published:
Monatshefte für Chemie / Chemical Monthly Aims and scope Submit manuscript

Summary

We report techniques for measuring optical rotation of suspended solids, including dissymmetric molecular crystals (e.g. sodium chlorate and bromate), synthetic polymers, polypeptides and biopolymers. Examples include poly(triphenylmethyl methacrylate), poly-S-lactide, poly-L-hydroxyproline, hemocyanine, cellulose acetate andRNA. The results indicate that optical rotation measurements are sensitive to differences in secondary structure and can serve as a probe for structural differences between solid-state and solution.

Zusammenfassung

Es wird über eine Methode zur Messung der optischen Rotation von Festkörpern in Suspensionen berichtet, wobei dissymetrische Kristalle (z. B. Natriumchlorat und -bromat), synthetische Polymere, Polypeptide und Biopolymere behandelt werden. Die Beispiele umfassen Poly(triphenylmethylmethacrylat), Poly-S-lactid, Poly-L-hydroxyprolin, Hemocyanin, Celluloseacetat undRNA. Die Ergebnisse zeigen, daß die optischen Rotationen bezüglich Unterschiede in der Sekundärstruktur empfindlich sind und daß diese Messungen als ein Maß für Strukturunterschiede zwischen Festzustand und Lösung herangezogen werden können.

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Authors and Affiliations

  1. Polytechnic University, 11201, Brooklyn, NY, USA

    Otto Vogl & Jan Bartus

  2. Advanced Materials Division, Central Research and Development Department, E.I. du Pont de Nemours & Co., Experimental Station, 19898, Wilmington, DE, USA

    Joseph R. Murdoch

Authors
  1. Otto Vogl
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  2. Jan Bartus
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  3. Joseph R. Murdoch
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Vogl, O., Bartus, J. & Murdoch, J.R. Solid-state, optical-rotation measurements on macromolecules using powder-suspensions. Monatsh Chem 121, 311–316 (1990). https://doi.org/10.1007/BF00808933

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  • DOI: https://doi.org/10.1007/BF00808933

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