Acta Neuropathologica

, Volume 19, Issue 4, pp 347–352

Progressive supranuclear palsy

Subcortical argyrophilic dystrophy

Authors

  • K. Jellinger
    • Neurological Institute of University of Vienna
Short Original Communications

DOI: 10.1007/BF00692156

Cite this article as:
Jellinger, K. Acta Neuropathol (1971) 19: 347. doi:10.1007/BF00692156

Summary

Two female cases of progressive supranuclear palsy (“heterogeneous system degeneration”) with histological findings are reported. Clinically, vertical gaze palsy, dystonia, akinesia, pseudobulbar palsy and mental impairment were prominent. Pathologically, widespread appearance of neurofibrillary tangles of the subcortical type in the brain stem and basal ganglia was associated with neuronal loss and gliosis in the substantia nigra, subthalamic nuclei and pallidum. There was less severe affection of the dentate nuclei and minimal cortical involvement. The distribution of changes in “subcortical argyrophilic dystrophy” is critically compared with and separated from brain stem affection in (pre)senile Alzheimer's disease.

Key words

Progressive Supranuclear Palsy Heterogenous System Degeneration Subcortical Argyrophilic Dystrophy Neurofibrillary Tangles Brain Stem

Copyright information

© Springer-Verlag 1971