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Timed sequential chemotherapy following ifosfamide-induced kinetic recruitment in refractory ovarian cancer

  • Ifosfamide, Chemotherapy, Ovarian Cancer
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Summary

A total of 22 relapsed or refractory ovarian cancer patients were treated with ifosfamide-containing polychemotherapy. Kinetic analyses were done to evaluate the tumor-cell-recruiting potential of the alkylating agent. Our study shows that ifosfamide can enhance tumor proliferative activity in pretreated ovarian cancers.

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References

  1. Aglietta M, Colly L (1979) Relevance of recruitment-synchronization in the scheduling of 1-beta-D-arabinofuranosylcytosine in a slow growing acute myeloid leukemia of the rat. Cancer Res 39:2727

    Google Scholar 

  2. Alama A, Favoni R, Trave F, Zarcone D, Conte PF (1984) Cell proliferative pattern in ovarian cancer patients following iphosphamide treatment: preliminary results. J Exp Clin Cancer Res 3:83

    Google Scholar 

  3. Braunschweiger PG, Schiffer LM (1978) Therapeutic implications of cell kinetic changes after cyclophosphamide treatment in spontaneous and transplantable mammary tumors. Cancer Treat Rep 62:727

    Google Scholar 

  4. Braunschweiger PG, Schiffer LM, (1980) Cell kinetic-directed sequential chemotherapy with cyclophosphamide and Adriamycin in T1699 mammary tumor. Cancer Res 40:737

    Google Scholar 

  5. Burke PJ, Vaughan WP, Karp JE (1980) A rationale for sequential high-dose chemotherapy of leukemia, timed to coincide with induced tumor proliferation. Blood 55:960

    Google Scholar 

  6. Conte PF, Fraschini G, Drewinko B, (1983) Estrogen induced expansion of the growth fraction in receptor negative human breast cancer (abstract). J Steroid Biochem 19:2138

    Google Scholar 

  7. Conte PF, Alama A, Favoni R, Trave F, Rosso R (1984) Timed sequential chemotherapy following drug-induced kinetic recruitment in refractory ovarian cancer. Eur J Cancer 20:1039

    Google Scholar 

  8. Conte PF, Bruzzone M, Chiara S (1986) A randomized trial comparing cisplatin plus cyclophosphamide versus cisplatin, doxorubicin and cyclophosphamide in advanced ovarian cancer. J Clin Oncol 4:965

    Google Scholar 

  9. Conte PF, Pronzato P, Rubagotti A, Alama A, Amadori D, Demicheli R, Gardin G, Gentilini P, Jacomuzzi A, Lionetto R, Monzeglio C, Nicolin A, Rosso R, Sismondi P, Sussio M, Santi L (1987) Conventional versus cytokinetic polychemotherapy with estrogenic recruitment in metastatic breast cancer: results of a randomized cooperative trial. J Clin Oncol 5:339

    Google Scholar 

  10. Dahl GV, Kalvinsky DK, Murphy S, Look AT, Amadori S, Kumar M, Novak R, George SL, Mason C, Mauer AM, Simone JV (1982) Cytokinetically based induction chemotherapy and splenectomy for childhood acute nonlymphocytic leukemia. Blood 60:856

    Google Scholar 

  11. Drewinko B, Brown BW, Humphrey R, Alexanian R (1974) Effect of chemotherapy on the labelling index of myeloma cells. Cancer 34:526

    Google Scholar 

  12. Drewinko B, Patchen M, Yang LY, Barlogie B (1981) Differential killing efficacy of twenty anti-tumor drugs on proliferating and non-proliferating human tumor cells. Cancer Res 41:2328

    Google Scholar 

  13. Gruppo Interegionale Cooperativo Oncologico Ginecologia (1987) Randomized comparison of cisplatin with cyclophosphamide/cis-platin and with cyclophosphamide/doxorubicin in advanced ovarian cancer. Lancet II:353

    Google Scholar 

  14. Holland JF (1983) Breaking the cure barrier. J Clin Oncol 1:75

    Google Scholar 

  15. Karp JE, Humphrey RL, Burke PJ (1981) Timed sequential chemotherapy of cytoxan-refractory multiple myeloma with cytoxan and Adriamycin based on induced proliferation. Blood 57:468

    Google Scholar 

  16. Markman M, Pendergrass KB, Abeloff MD (1982) Intensive timed sequential combination chemotherapy in extensive stage small cell carcinoma of the lung. Cancer Treat Rep 66:1880

    Google Scholar 

  17. Muggia FM (1980) New drugs in the treatment of ovarian cancer. In: Van Oosterom AT, Muggia FM, Cleton FJ (eds) Therapeutic progress in ovarian cancer, testicular cancer and the sarcomas. Leiden University Press, Leiden, p 129

    Google Scholar 

  18. Neijt JP, Ten Bokkel Huinink WW, Burg MEL van der, Oosterom AT van, Willemse PHB, Heintz A, Lent M van, Trimbos JB, Bouma J, Vermorken, Houwelingen JC van (1987) Randomized trial comparing two combination chemotherapy regimens (CHAP-5 vs CP) in advanced ovarian carcinoma. J Clin Oncol 5:1157

    Google Scholar 

  19. Pileri A, Conte PF, Hulin N (1976) Alkylating agents and myeloma cells. Blood 47:1056

    Google Scholar 

  20. Rosso R, Sertoli MR, Conte PF, Bruzzone M, Bentivoglio G, Pescetto G (1983) Cisplatinum, methotrexate and fluorouracil (PMF) combination chemotherapy in advanced ovarian cancer. Proc Am Soc Clin Oncol 2:C604

    Google Scholar 

  21. Salmon SE (1975) Expansion of the growth fraction in multiple myeloma with alkylating agents. Blood 45:119

    Google Scholar 

  22. Sanfilippo O, Daidone MG, Silvestrini R (1979) Antimetabolic effect of drug in short term culture as a potential tool for monitoring tumor chemosensitivity. Chemioter Oncol 4:261

    Google Scholar 

  23. Scheef W, Klein HO, Brock J, Burkert H, Günther U, Hoefer-Janker H, Mitrenga D, Schnitker J, Voigtmann R (1979) Controlled clinical studies with an antidote against the urotoxicity of oxazaphosphorines: preliminary results. Cancer Treat Rep 63:501

    Google Scholar 

  24. Silvestrini P, Piona P, Riccardi A, Rilke F (1977) Correlation of cell kinetic findings with morphology of non-Hodgkin's malignant lymphomas. J Natl Cancer Inst 58:499

    Google Scholar 

  25. Skipper HE, Perry S (1970) Kinetics of normal and leukemic leukocyte populations and relevance to chemotherapy. Cancer Res 30:1883

    Google Scholar 

  26. Skipper HE, Schabel FM, Wilcox WS (1967) Experimental evaluation of potential anticancer agents: XXI. Scheduling of arabinosylcytosine to take advantage of its S-phase specificity against leukemic cells. Cancer Chemother Rep 51:125

    Google Scholar 

  27. Smets LA, Taminiau J, Halen K, Waal F de, Behrendt H (1983) Cell kinetic responses in childhood acute nonlymphocytic leukemia during high dose therapy with cytosine arabinoside. Blood 61:79

    Google Scholar 

  28. Volm M, Wayss K, Kaufmann M, Mattern J (1979) Pretherapeutic detection of tumor resistance and the results of tumor chemotherapy. Eur J Cancer 15:983

    Google Scholar 

  29. Wogler WR, Cooper LE, Groth DP (1974) Correlation of cytosine arabinoside induced increment in growth fraction of leukemic blast cells with clinical response. Cancer 33:603

    Google Scholar 

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Rosso, R., Alama, A., Repetto, L. et al. Timed sequential chemotherapy following ifosfamide-induced kinetic recruitment in refractory ovarian cancer. Cancer Chemother. Pharmacol. 26 (Suppl 1), S43–S44 (1990). https://doi.org/10.1007/BF00685417

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