Originals

Neuroradiology

, Volume 33, Issue 4, pp 305-309

Decreased cerebral glucose metabolism associated with mental deterioration in multi-infarct dementia

  • K. MeguroAffiliated withDepartment of Geriatric Medicine, Tohoku University School of MedicineMiyama Hospital
  • , C. DoiAffiliated withDepartment of Psychology, Tohoku University School of Literature
  • , M. UedaAffiliated withMiyama Hospital
  • , T. YamaguchiAffiliated withDepartment of Geriatric Medicine, Tohoku University School of Medicine
  • , H. MatsuiAffiliated withDepartment of Radiology and Nuclear Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University
  • , S. KinomuraAffiliated withMiyama HospitalDepartment of Radiology and Nuclear Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University
  • , M. ItohAffiliated withCyclotron Radioisotope Center, Tohoku University School of Medicine
  • , K. YamadaAffiliated withDepartment of Radiology and Nuclear Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University
  • , H. SasakiAffiliated withDepartment of Geriatric Medicine, Tohoku University School of Medicine

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Summary

Cerebral glucose metabolism of 18 patients with multi-infarct dementia (MID) and 10 age-matched normal subjects were examined with positron emission tomography and the18-F-fluoro-deoxy-glucose technique. MID patients had significantly lower glucose metabolism in all the grey matter regions measured and were also characterized by more individuality in metabolic pattern. MID patients were also evaluated as to intelligence quotient (IQ). A positive correlation between IQ as shown by the Tanaka-Binet test and glucose metabolism for the entire grey matter was found. The clinical applicability of this test for predicting cerebral metabolism is discussed.

Key words

Senile dementia Multi-infarct dementia Intelligence quotient Glucose metabolism Positron emission tomography