Diabetologia

, Volume 34, Supplement 1, pp S141–S144

Effect of pancreas transplantation on life expectancy, kidney function and quality of life in uraemic Type 1 (insulin-dependent) diabetic patients

  • A. Secchi
  • V. Di Carlo
  • S. Martinenghi
  • E. La Rocca
  • R. Caldara
  • D. Spotti
  • G. Slaviero
  • C. Staudacher
  • G. Ferrari
  • G. Pozza
Quality of Life

DOI: 10.1007/BF00587642

Cite this article as:
Secchi, A., Di Carlo, V., Martinenghi, S. et al. Diabetologia (1991) 34: S141. doi:10.1007/BF00587642

Summary

The aim of our study was to evaluate the effects of haemodialysis, kidney transplantation and simultaneous kidney and pancreas transplantation on survival of diabetic subjects and on kidney function. 40 Type 1 (insulin-dependent) diabetic patients received a kidney transplantation: in 31 cases the kidney was transplanted simultaneously to a pancreas graft from the same donor (KP group), while in 9 cases the pancreas was not available (K group). 44 uraemic Type 1(insulin-dependent) diabetic patients on dialysis and in waiting list for kidney transplantation, constituted the control group (HD group). Patient survival rate 1, 3 and 5 years following transplantation was better in KP group (93%, 89%, 89%, respectively) than in K group (88%, 88%, 73%, respectively) and in HD group (88%, 62%, 51%, respectively). Kidney graft survival at 1, 3 and 5 years post-transplant was better in KP group (93%, 72%, 72%, respectively) than in K group (76%, 61%, 31%, respectively). 1 year after transplantation, patients of the KP group who had lost the pancreas for technical reasons (thrombosis) were included in the K group so as to evaluate the effect of the transplanted pancreas on long-term patient and kidney survival. Patient survival rate in the KP group (17 patients) at 2 and 4 years was 100%, while at the same intervals it was 78% in the K group (13 patients). Kidney graft function rate at 2 and 4 years was 93% in the KP group (17 grafts) and 54% and 27% respectively in the K group (14 grafts). Evaluation of quality of life in patients receiving a kidney and pancreas transplantation showed an improvement in psychological well-being, when compared to patients receiving a kidney transplantation alone. Physical well-being was similar in patients transplanted with kidney and pancreas or with kidney alone.

Key Words

Kidney transplantationPancreas transplantationLife expectancyQuality of life

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • A. Secchi
    • 1
  • V. Di Carlo
    • 2
  • S. Martinenghi
    • 1
  • E. La Rocca
    • 1
  • R. Caldara
    • 1
  • D. Spotti
    • 3
  • G. Slaviero
    • 3
  • C. Staudacher
    • 2
  • G. Ferrari
    • 2
  • G. Pozza
    • 1
  1. 1.Department of Internal MedicineIstituto Scientifico San RaffaeleMilanItaly
  2. 2.Department of SurgeryIstituto Scientifico San RaffaeleMilanItaly
  3. 3.Department of NephrologyIstituto Scientifico San RaffaeleMilanItaly