Summary
Chlorprothixene (CPX) and CPX sulphoxide were demonstrated in breast milk from two psychotic mothers taking 200 mg CPX daily. The milk concentrations of CPX were 120 to 260% greater than in plasma. The estimated amounts of drug administered in breast milk to one of the infants were 15 and 26 µg/day for CPX and CPX sulphoxide, respectively. Accordingly, the infant dose of the parent compound would be only 0.1% of the maternal dose/kg body weight. It is not likely that CPX or its metabolite would exert any immediate pharmacological effects in the nursing infant. However, the long term effect of low doses of neuroleptic drugs in the developing infants is not yet known.
References
Ahlenius S, Brown R, Engel I, Lundborg P (1973) Learning deficits in 4 weeks old offspring of the nursing mothers treated with the neuroleptic drug penfluridol. Arch Pharmacol (Berl) 279: 31–37
Christensen H (1974) Chlorprothixene and its metabolites in blood, liver and urine from fatal poisoning. Acta Pharmacol Toxicol 24: 16–26
Kirk L, Jørgensen A (1980) Concentrations of cix(Z)-flupentixol in maternal serum, amniotic fluid, umbilical cord, serum and milk. Psychopharmacology 72: 107–108
Lundborg P (1972) Abnormal ontogeny in young rabbits after chronic administration of haloperidol to the nursing mother. Brain Res 44: 684–687
Passwal M, Dahl SG, Refsum H (1976) Anticholinergic and cardiodepressive effects of chlorpromazine and two of its metabolites on isolated rat atria. Eur J Pharmacol 40: 249–254
Raaflaub J (1975) On the pharmacokinetics of chlorprotixene in man. Experientia 31: 557–558
Uhlir Rýznar I (1973) Appearance of chlorpromazine in the mother's milk. Activ Nerv Sup (Praha) 15: 106
Whitehead RG, Paul AA (1981) Infant growth and human milk requirements. Lancet 2: 161–163
Wiles DH, Orr MW, Kolakowska T (1978) Chlorpromazine levels in plasma and milk of nursing mothers. Br J Clin Pharmacol 5: 172
Wilson JT, Don Brown R, Cherek PR, Daily JW, Hilman B, Jobe PC, Manno BR (1980) Drug excretion in human breast milk. Principles, pharmacokinetics and projected consequences. Clin Pharmacokinet 5: 1–66
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Matheson, I., Evang, A., Fredricson Overø, K. et al. Presence of chlorprothixene and its metabolites in breast milk. Eur J Clin Pharmacol 27, 611–613 (1984). https://doi.org/10.1007/BF00556901
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00556901