Abstract
Cancer, the uncontrolled proliferation of a population of somatic cells, is fundamentally a genetic disorder. Although the specific array of genetic changes causing individual tumor types remains largely obscure, the past two decades have witnessed a tremendous increase in our understanding of the specific genes regulating cell differentiation, proliferation, and senescence. There appear to be two distinct fundamental genetic mechanisms of tumorigenesis. One mechanism is associated with the activation of growth-promoting factors such as proto-oncogenes. Altermatively, tumor formation may be induced as the result of the loss or inactivation of genes which normally regulate or suppress cell growth. These genes have been termed ‘tumor suppressor’ genes or ‘anti-oncogenes’. This review focuses on the role of ‘tumor suppressor’ genes in tumor formation and growth control of the human nervous system.
Similar content being viewed by others
References
Hanley MR: Neuron 1: 175–182, 1988
Klein G: Science 238: 1539–1544, 1987
Ponder B: Nature 335: 400–402, 1988
Hansen MF, Cavenee WK: Trends Genet 4: 125–128, 1988
Friend SH, et al.: Nature 323: 643–646, 1986
Lee W-H, et al.: Science 235: 1394–1399, 1987
Fung YKT, et al.: Science 235: 1657–1660, 1987
McGee TL, Yandell DW, Dryja TP: Gene 80: 119–128, 1989
Bookstein R, et al.: Proc Natl Acad Sci USA 85: 2210–2214, 1988
Lee W-H, et al.: Nature 329: 642–644, 1987
Whyte P, et al.: Nature 334: 124–126, 1988
Huang H-J, et al.: Science 242: 1563–1566, 1988
Harbour JW, et al.: Science 241: 353–356, 1988
Lee Y-H, et al.: Science 241: 218–221, 1988
Naylor SL, Johnson BE, Minna JD, Sakaguchi AY: Nature 329: 451–454, 1987
DeCaprio JA, et al: Cell 54: 275–283, 1988
Dyson N, Howley PM, Munger K, Harlow E: Science 243: 934–937, 1989
Robins PD, Horowitz JM, Mulligan RC: Nature 346: 668–671, 1990
Kimchi A, et al.: Science 240: 196–199, 1988
Wallace MR, et al.: Science 249: 181–186, 1990
Visconti D, et al.: Cell 62: 187–192, 1990
Cawthorn RM, et al.: Cell 62: 193–201, 1990
Ponder B: Nature 346, 703–704, 1990
Xu G: Cell 62: 599–608, 1990
DeCaprio JA, et al.: Cell 58: 1085–1095, 1989
Buchkovich K, Duffy LA, Harlow E: Cell 58: 1097–1105, 1989
Cheng P-L, et al.: Cell 58: 1193–1198, 1989
Ludlow JW, et al.: Cell 56: 57–65, 1989
Green MR: Cell 56: 1–3, 1989
Mowat MA, et al.: Nature 314: 633–636, 1985
Hinds PW, Finlay CA, Frey AB, Levine AJ: Mol Cell Biol 7: 2863–2869, 1984
Eliyahu D, Raz A, Gruss P, Givol D, Oren M: Nature 312: 646–649, 1984
James DC, Carlbom E, Nordenskiold M, Collins P, Cavenee WK: Proc Natl Acad Sci USA 86: 2858–2862, 1989
El-Azouzi M,et al.: Proc Natl Acad Sci USA, 1989, in press.
Vogelstein B, et al.: N Engl J Med 319: 525–529, 1988
Yokota J, et al.: Proc Natl Acad Sci USA 84: 9252–9256, 1987
Menon A, et al.: Proc Natl Acad Sci USA 87: 5435–5439, 1990
Nigro JM, et al.: Nature 342: 705–709, 1989
Chung R,et al.: Genes, Chromosomes and Cancer, 1991, in press.
Levine A, et al.: Nature 351: 453–456, 1991
Hollstein M, et al.: Science 253: 49–53, 1991
Malkin M, et al.: Science 250: 1233–1237, 1990
Srivastava S, et al.: Nature 348: 747–750, 1990
Knudson AG: Proc Natl Acad Sci USA 68: 820–824, 1971
Dunn JM, Phillips RA, Becker AJ, Gallie BL: Science 241: 1797–1801, 1988
Horowitz JM, et al.: Science 243, 937–940, 1989
Ibelgaufts H, Jones KW, Maitland N, Shaw JF: Acta Neuropathol 56: 113–117, 1982
Kitayama H, et al.: Cell 56: 77–84, 1989
Capecchi MR: Science 244: 1288–1292, 1989
Seizinger BR, et al.: Nature 332, 269–270, 1988
Mathew CGP, et al.: Nature 328: 524–527, 1987
Simpson NE, et al.: Nature 328: 528–531, 1987
Larsson K, et al.: Nature 332, 85–87, 1988
Barker D, et al.: Science 236: 1100–1102, 1987
Seizinger BR, et al.: Cell 49: 589–594, 1987
Seizinger BR, Martuza RL, Gusella JP: Nature 322: 664–667, 1986
Seizinger BR, et al.: Science 236: 317–319, 1987
Rouleau GA, et al.: Nature 329: 5419–5423, 1987
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Seizinger, B.R. Genes associated with tumor suppression and growth control in the human nervous system. Cancer Metast Rev 10, 281–287 (1991). https://doi.org/10.1007/BF00554790
Issue Date:
DOI: https://doi.org/10.1007/BF00554790