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Sensitivity of scopulariopsis brevicaulis to some antimicrobial agents

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Abstract

Sensitivity tests were done against two isolates of Scopulariopsis brevicaulis, using amphotericin B in combination with chloramphenicol, Chloramphenicol alone, amphotericin B in combination with 5-fluorocytosine, and 5-fluorocytosine, myxin and clotrimazole alone. Results indicated that the effectiveness of amphotericin B was improved in the presence of chloramphenicol or 5-fluorocytosine. Growth inhibitory values recorded for chloramphenicol alone and combined with amphotericin B did not show much variation. Resistance of the fungus has been noticed to 5-fluorocytosine; but the organism's response was much better when tested against 5-fluorocytosine in the presence of amphotericin B. Both myxin and clotrimazole proved very effective and their ED50 was 50 and 2.5 ug/ml of the medium, respectively. Thus, clotrimazole may be the drug of choice in the cases of deep scopulariopsis.

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  1. Provincial Laboratory of Public Health, The University of Alberta, T6G 2J2, Edmonton, Alberta, Canada

    Awatar S. Sekhon

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  1. Awatar S. Sekhon
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Sekhon, A.S. Sensitivity of scopulariopsis brevicaulis to some antimicrobial agents. Mycopathologia 57, 177–179 (1975). https://doi.org/10.1007/BF00551425

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  • DOI: https://doi.org/10.1007/BF00551425

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