European Journal of Clinical Pharmacology

, Volume 24, Issue 5, pp 667–670

Chronopharmacokinetic study of a prolonged release form of indomethacin

Authors

  • P. Guissou
    • Department of Physiology and Clinical PharmacologyERA CNRS 894, Faculty of Pharmacy
  • G. Cuisinaud
    • Department of Physiology and Clinical PharmacologyERA CNRS 894, Faculty of Pharmacy
  • G. Llorca
    • Rheumatology ClinicsHôpital des Charpennes
    • Department of Physiology and Clinical PharmacologyERA CNRS 894, Faculty of Pharmacy
  • E. Lejeune
    • Rheumatology ClinicsHôpital des Charpennes
    • Department of Physiology and Clinical PharmacologyERA CNRS 894, Faculty of Pharmacy
  • J. Sassard
    • Department of Physiology and Clinical PharmacologyERA CNRS 894, Faculty of Pharmacy
Originals

DOI: 10.1007/BF00542219

Cite this article as:
Guissou, P., Cuisinaud, G., Llorca, G. et al. Eur J Clin Pharmacol (1983) 24: 667. doi:10.1007/BF00542219

Summary

The chronopharmacokinetics of indomethacin was studied in patients with rheumatoid diseases after a single oral dose of a new prolonged-release form containing indomethacin 75 mg. The drug was given either at 8, 12 or 20 h and its plasma concentrations, as well as those of its main metabolite, O-desmethyl indomethacin, were followed using a new specific gas chromatographic assay. When given at 20 h plasma indomethacin concentrations did not exhibit a sharp peak and remained much more stable than when the drug was given at 8 or 12 h. In addition, plasma O-desmethyl indomethacin was significantly higher after administration of indomethacin at 20 h than at 8 or 12 h. It is concluded that the pharmacokinetics of the oral prolonged-release form of indomethacin exhibited chronobiological variation. The data are in accordance with clinical studies which suggest that it might be worthwhile to administer this formulation of indomethacin at 20 h.

Key words

indomethacinprolonged release formchrono-pharmacokineticsnocturnal dosingrheumatoid diseasesreduced side-effect
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Copyright information

© Springer-Verlag 1983