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Modification of actins by phallotoxins

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Abstract

Phallotoxins bind to filamentous actin (F-actin) from liver or rabbit muscle with K diss∼10−8 M. By this combination the structure of F-actin is stabilized to such an extent that it will be resistant to the depolymerizing action of 0.6M KI and of deoxyribonuclease I, to denaturation by heat (70 °° C), and to local ruptures caused by ultrasonication or by cytochalasin B. The structural features of phallotoxins essential for affinity to F-actin are specific.

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  1. Max-Planck-Institut für medizinische Forschung, Abteilung Naturstoff-Chemie, D-6900, Heidelberg

    Theodor Wieland

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  1. Theodor Wieland
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Wieland, T. Modification of actins by phallotoxins. Naturwissenschaften 64, 303–309 (1977). https://doi.org/10.1007/BF00446784

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  • DOI: https://doi.org/10.1007/BF00446784

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