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Chromosome translocation (2;13) (q37;q14) in a disseminated alveolar rhabdomyosarcoma

  • Medical Genetics
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Abstract

Chromosome analysis of tumour cells in the bone marrow of a 13.5-year-old girl (without a primary tumour) revealed a pseudo-diploid or pseudo-tetraploid karyotype with a translocation involving the long arms of chromosomes 2 and 13: t(2;13) (q37;q14). This finding enabled the diagnosis of a disseminated alveolar rhabdomyosarcoma (RMS) to be established. The patient was treated by cytotoxic chemotherapy, went into complete remission, but died of relapse 14 months after diagnosis. As several cases with this translocation have been described recently, this additional report confirms that t(2;13) is specific for the alveolar subtype of RMS.

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Abbreviations

RMS:

rhabdomyosarcoma

RPMI:

Roswell Park Memorial Institute

FCS:

foetal calf serum

nm:

modal number

References

  1. Gutjahr P, Hütteroth H, Meyer WM (1976) Das primär generalisierte alveoläre Rhabdomyosarkom. Klin Pädiatr 188:372–378

    Google Scholar 

  2. Lai J-L, Savary J-B, Deminatti M, Demaille M-C, Baranzelli M-C (1987) Translocation (2;13)(q37;q14) in rhabdomyosarcoma: a new case. Cancer Genet Cytogenet 25:371–372

    Google Scholar 

  3. Lizard-Nacol S, Mugneret F, Volk C, Ture-Carel C, Favrot M, Philip T (1987) Translocation (2;13)(q37;q14) in alveolar rhabdomyosarcoma: a new case. Cancer Genet Cytogenet 25:373–374

    Google Scholar 

  4. Trent J, Casper J, Meltzer P, Thompson F, Fogh J (1986) Nonrandom chromosome alterations in rhabdomyosarcoma. Cancer Genet Cytogenet 16:189–197

    Google Scholar 

  5. Treuner J, Altmannsberger M, Niethammer D (1986) Soft tissue sarcomas. Monogr Paediatr 18:243–263

    Google Scholar 

  6. Turc-Carel C, Lizard-Nacol S, Justrabo E, Favrot M, Philip T, Tabone E (1986) Consistent chromosomal translocation in alveolar rhabdomyosarcoma. Cancer Genet Cytogenet 19:361–362

    Google Scholar 

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Engel, R., Ritterbach, J., Schwabe, D. et al. Chromosome translocation (2;13) (q37;q14) in a disseminated alveolar rhabdomyosarcoma. Eur J Pediatr 148, 69–71 (1988). https://doi.org/10.1007/BF00441819

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  • DOI: https://doi.org/10.1007/BF00441819

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