Abstract
Δ9-Tetrahydrocannabinol (2.5–80.0 mg/kg) significantly prolonged the anaesthesia induced by ketamine, pentobarbitone, thiopentone, propanidid, and Alfathesin® in a dose-dependent manner. Cannabinol and cannabidiol (both 5.0–80.0 mg/kg) were essentially inactive, except that cannabidiol prolonged pentobarbitone-induced anaesthesia. The interaction of Δ9-tetrahydrocannabinol with the anaesthetic agents was postulated to be due to a centrally mediated action, whereas the effect of cannabidiol on pentobarbitone-induced anaesthesia probably depended on a metabolic interaction. The interaction between the cannabinoids in influencing anaesthesia induced by the above agents was examined, and the interactions were found to be complex.
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Anderson, P. F., Jackson, D. M., Chesher, G. B.: Interaction of Δ9-tetrahydrocannabinol and cannabidiol on intestinal motility in mice. J. Pharm. Pharmacol. 26, 136–137 (1974)
Bosé, B. C., Saifi, A. Q., Bhagwat, A. W.: Studies on pharmacological actions of Cannabis indica (Lynn). III. Arch. Int. Pharmacodyn. Ther. 147, 291–297 (1964)
Card, B., McCulloch, R. J., Pratt, D. A. H.: Tissue distribution of CT1341 in the rat; an autoradiographic study. Postgrad. Med. J. 48, [Suppl. 2], 34 (1972)
Chesher, G. B., Jackson, D. M.: Anticonvulsant effects of cannabinoids in mice: drug interactions within cannabinoids and cannabinoid interactions with phenytoin. Psychopharmacologia (Berl.) 37, 255–264 (1974)
Chesher, G. B., Jackson, D. M., Starmer, G. A.: Interaction of cannabis and general anaesthetic agents in mice. Br. J. Pharmacol. 50, 593–599 (1974)
Chesher, G. B., Jackson, D. M., Malor, R. M.: Interaction of Δ9-tetrahydrocannabinol and cannabidiol with phenobarbitone in protecting mice from electrically induced convulsions. J. Pharm. Pharmacol. 27, 608–609 (1975)
Child, K. J., Gibson, W., Harnley, G., Hart, J. W.: Metabolism and excretion of Althesin (CT1341) in the rat. Postgrad. Med. J. 48 [Suppl. 2], 37 (1972)
Cohen, G. M., Peterson, D. W., Mannering, G. J.: Interaction of Δ9-tetrahydrocannabinol with the hepatic microsomal drug metabolising system. Life Sci. 10, 1207–1215 (1971)
Fernandes, M., Schabarek, A., Coper, H., Hill, R.: Modification of Δ9-tetrahydrocannabinol by cannabinol and cannabidiol in the rat. Psychopharmacologia (Berl.) 38, 329–338 (1974)
Gill, E. W., Paton, W. D. M., Pertwee, R. G.: Preliminary experiments on the chemistry and pharmacology of cannabis. Nature 228, 134–136 (1970)
Harvey, S. C.: Hypnotics and sedatives: the barbiturates. In: The pharmacological basis of therapeutics, 5th ed., L. S. Goodman and A. Gilman, eds., pp. 102–103. New York: McMillan 1975
Herrington, L. P.: The heat regulation of small laboratory animals at various environmental temperatures. Am. J. Physiol. 129, 123–139 (1940)
Karniol, I. G., Carlini, E. A.: Comparative studies in man and in laboratory animals on of Δ8-and Δ9-trans-tetrahydrocannabinol.Pharmacology 9, 115–126 (1973)
Krantz, J. C., Berger, H. J., Welch, B. L.: Blockade of (-)trans-Δ9-tetrahydrocannabinol depressant effect by cannabinol in mice. Am. J. Pharm. 143, 149–152 (1971)
Kubena, R. K., Barry, H.: Interactions of Δ1THC with barbiturates and methamphetamine. J. Pharmacol. Exp. Ther. 173, 94–100 (1970)
Lawrence, D. K., Gill, E. W.: Structurally specific effects of some steroid anaesthetics on spin-labeled liposomes. Mol. Pharmacol. 11, 280–286 (1975a)
Lawrence, D. K., Gill, E. W.: The effect of Δ1-tetrahydrocannabinol and other cannabinoids on spin-labeled liposomes and their relationship to mechanisms of general anaesthesia. Mol. Pharmacol. 11, 595–602 (1975b)
McCarthy, D. A.: The pharmacology of Ketalar®: a review of laboratory studies. In: “Ketalar”, pp. 13–36. Canada: Parke Davis 1971
Malor, R., Jackson, D. M., Chesher, G. B.: The effect of Δ9-tetrahydrocannabinol, cannabidiol and cannabinol on ether anaesthesia in mice. J. Pharm. Pharmacol. 27, 610–612 (1975)
Paton, W. D. M., Pertwee, R. G.: Effect of cannabis and certain of its constituents on phenobarbital sleeping time and phenazone metabolism. Br. J. Pharmacol. 44, 250–261 (1972)
Paton, W. D. M., Pertwee, R. J., Temple, D. M.: The general pharmacology of cannabinoids. In: Cannabis and its derivatives, pharmacology and experimental psychology, W. D. M. Paton and J. Crown, eds., pp. 50–74 Oxford: Oxford University Press 1972
Perez-Reyes, M., Timmons, M. C., Davis, K. H., Wall, E. M.: A comparison of the pharmacological activity in man of intravenously administered Δ9-tetrahydrocannabinol, cannabinol and cannabidiol. Experientia 29, 1368–1369 (1973)
Pütter, J.: Über den fermentativen Abbau des Propanidid. Anaesth. Resusc 4, 61–77 (1965)
Sofia, R. D., Barry, H.: Depressant effect of Δ9-tetrahydrocannabinol enhanced by inhibition of its metabolism. Eur. J. Pharmacol. 13, 134–137 (1970)
Welburn, P. J., Starmer, G. A., Chesher, G. B., Jackson, D. M.: Effect of cannabinoids on the abdominal constriction response in mice: within cannabinoid interactions. Psychopharmacologia (Berl.) 46, 83–85 (1976)
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Frizza, J., Chesher, G.B., Jackson, D.M. et al. The effect of Δ9, cannabidiol, and cannabinol on the anaesthesia induced by various anaesthetic agents in mice. Psychopharmacology 55, 103–107 (1977). https://doi.org/10.1007/BF00432824
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DOI: https://doi.org/10.1007/BF00432824