Psychopharmacology

, Volume 73, Issue 1, pp 95–96

A preliminary double-blind study on the efficacy of carbamazepine in prophylaxis of manic-depressive illness

  • Teruo Okuma
  • Kazutoyo Inanaga
  • Saburo Otsuki
  • Keisuke Sarai
  • Ryo Takahashi
  • Hidefumi Hazama
  • Atsuyoshi Mori
  • Shôsuke Watanabe
Short Reports

DOI: 10.1007/BF00431111

Cite this article as:
Okuma, T., Inanaga, K., Otsuki, S. et al. Psychopharmacology (1981) 73: 95. doi:10.1007/BF00431111

Abstract

A preliminary double-blind controlled study on the prophylactic effect of carbamazepine on recurrent manic-depressive psychotics was conducted with 22 patients using an inert placebo in ten subjects as a control drug. Carbamazepine in the dosage of 200–600 mg was administered for 1 year. Among the 22 carbamazepine subjects, carbamazepine was found to be effective in 60% of the cases and inert placebo in 22.2% (U-test, P<0.10). It is suggested that carbamazepine is a useful drug for the prophylaxis of manic-depressive illness.

Key words

CarbamazepineProphylaxisManic-depressive psychosisDouble-blind controlled trial

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Teruo Okuma
    • 1
  • Kazutoyo Inanaga
    • 2
  • Saburo Otsuki
    • 3
  • Keisuke Sarai
    • 4
  • Ryo Takahashi
    • 5
  • Hidefumi Hazama
    • 6
  • Atsuyoshi Mori
    • 7
  • Shôsuke Watanabe
    • 8
  1. 1.Department of PsychiatryTohoku University School of MedicineSendaiJapan
  2. 2.Department of PsychiatryKurume University School of MedicineKurumeJapan
  3. 3.Department of PsychiatryOkayama University School of MedicineOkayamaJapan
  4. 4.Department of PsychiatryHiroshima University School of MedicineHiroshimaJapan
  5. 5.Department of PsychiatryNagasaki University School of MedicineNagasakiJapan
  6. 6.Department of PsychiatryTottori University School of MedicineYonagoJapan
  7. 7.Department of PsychiatryToho University School of MedicineTokyoJapan
  8. 8.Department of PsychiatryKawasaki Medical SchoolKurashikiJapan