, Volume 73, Issue 1, pp 95–96

A preliminary double-blind study on the efficacy of carbamazepine in prophylaxis of manic-depressive illness


  • Teruo Okuma
    • Department of PsychiatryTohoku University School of Medicine
  • Kazutoyo Inanaga
    • Department of PsychiatryKurume University School of Medicine
  • Saburo Otsuki
    • Department of PsychiatryOkayama University School of Medicine
  • Keisuke Sarai
    • Department of PsychiatryHiroshima University School of Medicine
  • Ryo Takahashi
    • Department of PsychiatryNagasaki University School of Medicine
  • Hidefumi Hazama
    • Department of PsychiatryTottori University School of Medicine
  • Atsuyoshi Mori
    • Department of PsychiatryToho University School of Medicine
  • Shôsuke Watanabe
    • Department of PsychiatryKawasaki Medical School
Short Reports

DOI: 10.1007/BF00431111

Cite this article as:
Okuma, T., Inanaga, K., Otsuki, S. et al. Psychopharmacology (1981) 73: 95. doi:10.1007/BF00431111


A preliminary double-blind controlled study on the prophylactic effect of carbamazepine on recurrent manic-depressive psychotics was conducted with 22 patients using an inert placebo in ten subjects as a control drug. Carbamazepine in the dosage of 200–600 mg was administered for 1 year. Among the 22 carbamazepine subjects, carbamazepine was found to be effective in 60% of the cases and inert placebo in 22.2% (U-test, P<0.10). It is suggested that carbamazepine is a useful drug for the prophylaxis of manic-depressive illness.

Key words

CarbamazepineProphylaxisManic-depressive psychosisDouble-blind controlled trial

Copyright information

© Springer-Verlag 1981