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Stimulus effects of Δ9-THC and its interaction with naltrexone and catecholamine blockers in rats

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Abstract

Rats trained in a T-shaped maze to discriminate the effects of i.p. injections of Δ9-tetrahydrocannabinol (Δ9-THC, 4mg/kg) and the effects of the vehicle were tested for antagonism and generalization to the Δ9-THC stimulus by naltrexone (4 mg/kg), haloperidol (0.32 mg/kg), propranolol (20 mg/kg), and phenoxybenzamine (10 mg/kg). None of these drugs blocked the Δ9-THC stimulus, nor were they found to generalize to Δ9-THC.

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Authors and Affiliations

  1. Department of Psychology, University of Uppsala, Box 227, S-751 04, Uppsala, Sweden

    T. U. C. Järbe & G. Ch. Ohlin

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  1. T. U. C. Järbe
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  2. G. Ch. Ohlin
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Järbe, T.U.C., Ohlin, G.C. Stimulus effects of Δ9-THC and its interaction with naltrexone and catecholamine blockers in rats. Psychopharmacology 54, 193–195 (1977). https://doi.org/10.1007/BF00426779

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  • DOI: https://doi.org/10.1007/BF00426779

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