Psychopharmacologia

, Volume 22, Issue 1, pp 23–30

The effect of two tetrahydrocannabinols, (Δ9-THC and Δ8-THC) on conditioned avoidance learning in rats and its transfer to normal state conditions

Authors

  • Bengt G. Henriksson
    • Department of PsychologyUniversity of Uppsala
    • Neurophysiological Laboratory, Psychiatric Research CenterUlleråker Hospital
  • Torbjörn Järbe
    • Department of PsychologyUniversity of Uppsala
    • Neurophysiological Laboratory, Psychiatric Research CenterUlleråker Hospital
Original Investigations Animal Studies

DOI: 10.1007/BF00401463

Cite this article as:
Henriksson, B.G. & Järbe, T. Psychopharmacologia (1971) 22: 23. doi:10.1007/BF00401463

Abstract

Rats trained in conditioned avoidance responding (CAR) after injections of either 7.5 mg/kg Δ 9-THC (tetrahydrocannabinol) or 15 mg/kg Δ 8-THC, showed no transfer when tested in the non-drugged state. Furthermore, these doses of the isomeric tetrahydrocannabinols exerted a disruptive effect on previously established CAR in rats, trained under normal conditions.

Only the Δ 9-THC-group showed an impairment of acquisition which was statistically significant compared to the control group.

Key-Words

Acquisition CAR Tetrahydrocannabinols Transfer Rat

Copyright information

© Springer-Verlag 1971