Original Investigations Animal Studies

Psychopharmacologia

, Volume 22, Issue 1, pp 23-30

First online:

The effect of two tetrahydrocannabinols, (Δ9-THC and Δ8-THC) on conditioned avoidance learning in rats and its transfer to normal state conditions

  • Bengt G. HenrikssonAffiliated withDepartment of Psychology, University of UppsalaNeurophysiological Laboratory, Psychiatric Research Center, Ulleråker Hospital
  • , Torbjörn JärbeAffiliated withDepartment of Psychology, University of UppsalaNeurophysiological Laboratory, Psychiatric Research Center, Ulleråker Hospital

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Abstract

Rats trained in conditioned avoidance responding (CAR) after injections of either 7.5 mg/kg Δ 9-THC (tetrahydrocannabinol) or 15 mg/kg Δ 8-THC, showed no transfer when tested in the non-drugged state. Furthermore, these doses of the isomeric tetrahydrocannabinols exerted a disruptive effect on previously established CAR in rats, trained under normal conditions.

Only the Δ 9-THC-group showed an impairment of acquisition which was statistically significant compared to the control group.

Key-Words

Acquisition CAR Tetrahydrocannabinols Transfer Rat