The effect of two tetrahydrocannabinols, (Δ9-THC and Δ8-THC) on conditioned avoidance learning in rats and its transfer to normal state conditions
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- Henriksson, B.G. & Järbe, T. Psychopharmacologia (1971) 22: 23. doi:10.1007/BF00401463
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Rats trained in conditioned avoidance responding (CAR) after injections of either 7.5 mg/kg Δ9-THC (tetrahydrocannabinol) or 15 mg/kg Δ8-THC, showed no transfer when tested in the non-drugged state. Furthermore, these doses of the isomeric tetrahydrocannabinols exerted a disruptive effect on previously established CAR in rats, trained under normal conditions.
Only the Δ9-THC-group showed an impairment of acquisition which was statistically significant compared to the control group.