, Volume 113, Issue 4, pp 376-378

Reversible arrhythmias observed in patients treated with recombinant alpha2 interferon

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We have treated 25 patients, 7 with breast cancer and 18 with non-Hodgkin's lymphoma, with recombinant alpha2 interferon. In 5 patients we observed cardiac arrhythmias that were unexpected and required treatment. No deaths have occured that we can attribute to interferon, though 1 patient had to be resuscitated. Age, prior cardiac disease, prior treatment with doxorubicin, and interferon dose appear to be predisposing factors for this toxicity.

Supported by the Schering Corporation and Harper-Grace Hospitals