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Reversible arrhythmias observed in patients treated with recombinant alpha2 interferon

  • Original Papers
  • Clinical Oncology or Epidemiology
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Summary

We have treated 25 patients, 7 with breast cancer and 18 with non-Hodgkin's lymphoma, with recombinant alpha2 interferon. In 5 patients we observed cardiac arrhythmias that were unexpected and required treatment. No deaths have occured that we can attribute to interferon, though 1 patient had to be resuscitated. Age, prior cardiac disease, prior treatment with doxorubicin, and interferon dose appear to be predisposing factors for this toxicity.

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Authors and Affiliations

  1. Department of Medicine, Wayne State University School of Medicine, and Harper-Grace Hospital, 48201, Detroit, MI, USA

    Silvana Martino (Assistant Professor of Medicine), Voravit Ratanatharathorn, Chatchada Karanes, Bohumil A. Samal, Young Ho Sohn & Seth A. Rudnick

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  1. Silvana Martino
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  2. Voravit Ratanatharathorn
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  3. Chatchada Karanes
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  4. Bohumil A. Samal
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  5. Young Ho Sohn
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  6. Seth A. Rudnick
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Supported by the Schering Corporation and Harper-Grace Hospitals

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Martino, S., Ratanatharathorn, V., Karanes, C. et al. Reversible arrhythmias observed in patients treated with recombinant alpha2 interferon. J Cancer Res Clin Oncol 113, 376–378 (1987). https://doi.org/10.1007/BF00397722

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  • DOI: https://doi.org/10.1007/BF00397722

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