Summary
The purpose of this study was to investigate the effects of physical training on the responses of serum adrenocorticotropic hormone (ACTH) and cortisol concentration during low-intensity prolonged exercise. Five subjects who had fasted for 12 h cycled at the same absolute intensity that elicited 50% of pre-training maximal oxygen uptake (\(\dot V\)O2max), either until exhaustion or for up to 3 h, before and after 7 weeks of vigorous physical training [mean daily energy consumption during training exercise, 531 kcal (2230 kJ)]. In the pre-training test, serum ACTH and cortisol concentrations did not increase during the early part of the exercise. Increases in concentrations of both hormones occurred in all subjects when blood glucose concentration decreased during the later phase of the exercise. The mean values and SEM of serum ACTH and cortisol concentrations at the end of the exercise were 356 ng · l−1, SEM 79 and 438 μg · l−1, SEM 36, respectively. After the physical training, \(\dot V\)O2max of the subjects improved significantly from the mean value of 50.2 ml · kg−1 · min−1, SEM 2.5 to 57.3 ml · kg−1 · min−1, SEM 2.0 (P < 0.05). In the post-training test, exercise time to exhaustion was prolonged in three subjects. Comparing the pre- and post training values observed after the same length of time that the subjects had exercised in the pre-training test, the post-training values of serum ACTH (44 ng · l−1, SEM 3) and cortisol (167 μg · l−1, SEM 30) concentration were less than the pre-training value (P < 0.05). However, after the subjects stopped exercising in the post-training test, the serum ACTH (214 ng · l−1, SEM 49) and cortisol (275 μg · l−1, SEM 50) concentrations were not significantly different from those measured after the subjects stopped exercising in the pre-training test (P > 0.10). In conclusion, high-intensity physical training reduced the responses of both hormones during prolonged exercise, propbably because of a delayed decrease of blood glucose concentration after physical training, while the level of the blood glucose concentration which induces ACTH and cortisol secretion did not change.
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References
Atomi Y, Miyashita M (1980) Effect of training intensity in adult females on aerobic power, related to lean body mass. Eur J Appl Physiol 44:109–116
Brožek J, Grande F, Anderson JT, Keys A (1963) Densitometric analysis of body composition: review of some quantitative assumptions. Ann NY Acad Sci 110:113–140
Davies CTM, Few JD (1973) Effect of exercise on adrenocortical function. J Appl Physiol 35:887–891
Farrell PA, Garthwaite TL, Gustafson AB (1983) Plasma adrenocorticotropin and cortisol responses to submaximal and exhaustive exercise. J Appl Physiol 55:1441–1444
Galbo H (1983) Hormonal and metabolic adaptations to exercise. Thieme, Stuttgart and Thieme-Stratton, New York
Galbo H, Holst JJ, Christensen NJ (1979) The effect of different diets and of insulin on the hormonal responses to prolonged exercise. Acta Physiol Scand 107:19–32
Hartley LH, Mason JM, Hogan RP, Jones LG, Kotchen TA, Mougey EH, Wherry FE, Pennington LL, Ricketts PT (1972a) Multiple hormonal responses to graded exercise in relation to physical training. J Appl Physiol 33:602–606
Hartley LH, Mason JW, Hogan RP, Jones LG, Kotchen TA, Mougey EH, Wherry FE, Pennington LL, Ricketts PT (1972b) Multiple hormonal responses to prolonged exercise in relation to physical training. J Appl Physiol 33:607–610
Hermansen L, Pruet EDP, Osnes J-B, Giere FA (1970) Blood glucose and insulin response to maximal exercise and glucose infusion. J Appl Physiol 29:13–16
Hickson RC, Bomze HA, Holloszy JO (1977) Linear increase in aerobic power induced by strenuous program of endurance exercise. J Appl Physiol Respir Environ Exerc Physiol 42:372–376
Hurley BF, Nemeth PM, Martin III WH, Hagberg JM, Dalsky GP, Holloszy JO (1986) Muscle triglyceride utilization during exercise: effect of training. J Appl Physiol 60:562–567
Kellar-Wood ME, Dallman MF (1984) Corticosteroid inhibition of ACTH secretion. Endocr Rev 5:1–24
Kjær M, Mikines K, Christensen NJ, Tronier B, Vinten J, Sonne B, Richter EA, Galbo H (1984) Glucose turnover and hormonal changes during insulin-induced hypoglycemia in trained humans. J Appl Physiol Respir Environ Exerc Physiol 57:21–27
Kjær M, Bangsbo J, Lortie G, Galbo H (1988) Hormonal responses to exercise in humans: influence of hypoxia and physical training. Am J Physiol 254 (Regulatory Integrative Comp Physiol 23): R197-R203
Luger A, Deuster PA, Kyke SB, Gallucci WT, Montgomery LC, Gold PW, Lariaux DL, Chrousos GP (1987) Acute-hypothalamus-pituitary-adrenal responses to the stress of treadmill exercise. Physiological adaptations to physical training. New Engl J Med 316:1309–1315
Scholander PF (1947) Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. J Biol Chem 167:235–250
Tabata I, Atomi Y, Miyashita M (1984) Blood glucose concentration dependent ACTH and cortisol responses to prolonged exercise. Clin Physiol 4:299–307
Widmaier EP, Olotsky PM, Sutton SW, Valve WW (1988) Regulation of corticotropin releasing factor secretion in vitro by glucose. Am J Physiol 255 (Endocrinol Metab 18):E287-E292
Winder WW, Hickson RC, Hagberg JM, Ehsani AA, McLane JA (1979) Training-induced changes in hormonal and metabolic responses to submaximal exercise. J Appl Physiol Respir Environ Exerc Physiol 46:766–771
Winder WW, Beattie MA, Holman RT (1982) Endurance training attenuates stress hormone responses to exercise in fasted rats. Am J Physiol 243 (Regulatory Integrative Comp Physiol 12): R179-R184
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Tabata, I., Atomi, Y., Mutoh, Y. et al. Effect of physical training on the responses of serum adrenocorticotropic hormone during prolonged exhausting exercise. Eur J Appl Physiol 61, 188–192 (1990). https://doi.org/10.1007/BF00357597
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DOI: https://doi.org/10.1007/BF00357597