Human Genetics

, Volume 64, Issue 2, pp 116–121

Clinical heterogeneity in the tricho-dento-osseous syndrome

Authors

  • F. Quattromani
    • Department of Radiology2nd General Hospital
  • S. D. Shapiro
    • Department of Periodontics and Genetics School of DentistryUniversity of Texas Health Science Center
  • R. S. Young
    • Department of Periodontics and Genetics School of DentistryUniversity of Texas Health Science Center
  • R. J. Jorgenson
    • Department of Periodontics and Genetics School of DentistryUniversity of Texas Health Science Center
  • J. W. Parker
    • Department of PediatricsBrooke Army Medical Center
  • R. Blumhardt
    • the Department of RadiologyBrooke Army Medical Center
  • R. R. Reece
    • Department of RadiologyWilliam Beaumont Army Medical Center
Original Investigations

DOI: 10.1007/BF00327105

Cite this article as:
Quattromani, F., Shapiro, S.D., Young, R.S. et al. Hum Genet (1983) 64: 116. doi:10.1007/BF00327105

Summary

The tricho-dento-osseous syndrome (TDO syndrome) involves morphologic abnormalities of hair, teeth, and skeleton. Clinical findings of the TDO syndrome are excessively curly (fuzzy) hair, enamel hypoplasia, and skeletal findings of a generalized pattern of osseous sclerosis. We report an autosomal dominant syndrome with similar hair and teeth morphology, but with a skeletal dysplasia consisting of sclerosis and thickening of the calvarium with long bones that show subtle undertubulation but no sclerosis.

Copyright information

© Springer-Verlag 1983