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Idiopathic refractory sideroachrestic anemia (IRSA) progressing to acute mixed lymphoblastic-myelomonoblastic leukemia

Case report and review of the literature

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Summary

A longitudinal observation of a patient with idiopathic refractory sideroachrestic anemia (IRSA) progressing to acute mixed lymphoblastic-myelomonoblastic leukemia is reported. The leukemia was characterized by morphology, immunological cell markers, and dissociated clinical responsiveness to vincristine/prednisone and arabinosylcytosine/6-thioguanine. Attention is paid to the hematological changes prior to leukemia development. Acute leukemia was best heralded in this patient by a severe deterioration of dyserythropoiesis and by an increase of blasts in the marrow to more than 5%. The observed preleukemic features are compared to those described in the literature.

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Authors and Affiliations

  1. Medizinische Poliklinik der Universität München, Pettenkoferstr. 8a, D-8000, München 2, Federal Republic of Germany

    R. Hehlmann, B. Zönnchen & B. Walther

  2. Medizinische Klinik Innenstadt der Universität München, Ziemssenstr. 1, D-8000, München 2, Federal Republic of Germany

    E. Thiel

Authors
  1. R. Hehlmann
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  2. B. Zönnchen
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  3. E. Thiel
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  4. B. Walther
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Supported in part by the Deutsche Forschungsgemeinschaft (SFB 51)

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Hehlmann, R., Zönnchen, B., Thiel, E. et al. Idiopathic refractory sideroachrestic anemia (IRSA) progressing to acute mixed lymphoblastic-myelomonoblastic leukemia. Blut 46, 11–21 (1983). https://doi.org/10.1007/BF00320001

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  • DOI: https://doi.org/10.1007/BF00320001

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