Summary
Human pharmacokinetic data on the new antiparasitic agent, ivermectin, are scanty. For the evaluation of its disposition a specific HPLC assay with sensitive fluorescence detection was developed. Applying equilibrium dialysis, plasma protein binding of ivermectin was measured in five healthy individuals and it averaged 93.2±4.4% (SD). Such strong binding should be taken into consideration, especially in patients with malnutrition or with diseases in which a decrease in plasma proteins and consequently a higher free fraction of ivermectin could be expected.
References
Awadzi K, Dadzie KY, Schulz-Key H, Haddock DRW, Gilles HM, Aziz MA (1985) The chemotherapy of onchocerciasis X. An assessment of four single dose regimens of MK-933 (ivermectin) in human onchocerciasis. Ann Trop Med Parasitol 79: 63078
WHO Tropical Diseases Bulletin, Geneva, Switzerland, 1988
Edwards G, Dingsdale A, Helsby N, Orme MLE, Breckenridge AM (1988) The relative systemic availability of ivermectin after administration as capsule, tablet and oral solution. Eur J Clin Pharmacol 35: 681–684
Krishna DR, Klotz U (1990) Determination of ivermectin in human plasma and urine by high-performance liquid chromatography. (in preparation)
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Klotz, U., Ogbuokiri, J.E. & Okonkwo, P.O. Ivermectin binds avidly to plasma proteins. Eur J Clin Pharmacol 39, 607–608 (1990). https://doi.org/10.1007/BF00316107
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DOI: https://doi.org/10.1007/BF00316107