Journal of Neurology

, Volume 236, Issue 5, pp 292–295

Neurogenic muscle hypertrophy

Report of two cases


  • D. Pareyson
    • Istituto Neurologico “C. Besta”
  • L. Morandi
    • Istituto Neurologico “C. Besta”
  • V. Scaioli
    • Istituto Neurologico “C. Besta”
  • R. Marazzi
    • Istituto Neurologico “C. Besta”
  • A. Boiardi
    • Istituto Neurologico “C. Besta”
  • A. Sghirlanzoni
    • Istituto Neurologico “C. Besta”
Short Communications

DOI: 10.1007/BF00314459

Cite this article as:
Pareyson, D., Morandi, L., Scaioli, V. et al. J Neurol (1989) 236: 292. doi:10.1007/BF00314459


Muscle hypertrophy is rare in denervating diseases. A patient with calf enlargement associated with L5–S1 radiculopathy and another with thenar, hypothenar, forearm and calf muscle hypertrophy in the course of chronic relapsing inflammatory demyelinating polyneuropathy are described. Gastrocnemius muscle biopsy revealed both type I and type II fibre hypertrophy in the former case and predominant type I fibre hypertrophy in the latter. Passive stretching and abnormal spontaneous muscular activity might have played a role in the origin of hypertrophy in both patients, but a satisfactory explanation for denervation hypertrophy has yet to be provided.

Key words

Muscle hypertrophy Neuropathies Spontaneous muscular activity Stretching

Copyright information

© Springer-Verlag 1989