Abstract
Juvenile gigantomastia in a 12-year-old girl was treated by a bilateral reduction mammoplasty with free transplantation of the areolae and nipples and the removal of 3,980 g of breast tissue. Regrowth of the residual breast tissue has been suppressed by the administration of tamoxifen, an antiestrogen drug, since the surgery. This case was positive for estrogen receptors (ER) by the dextran-coated charcoal method, while tissue staining for ER and estradiol resulted in a darker staining of the epithelial contents, especially of fibroadenoma-like nodules, using an immunocytochemical assay. It is thus suggested that the etiology of this disease might be related to a local hypersensitivity to estrogen.
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References
Lewis D, Geschickter CF (1934) Gynecomastia, virginal hypertrophy, and fibroadenomas of the breast. Ann Surg 100:779–795
Fisher W, Smith JW (1971) Macromastia during puberty. Plast Reconstr Surg 47:445–451
Sperling LS, Gold JJ (1973) Use of an anti-estrogen after a reduction mammoplasty to prevent recurrence of virginal hypertrophy of breasts. Plast Reconstr Surg 52:439–442
Mayl N, Vasconez LO, Jurkewicz MJ (1974) Treatment of macromastia in the actively enlarging breast. Plast Reconstr Surg 54:6–12
Mori T, Morimoto T, Komaki K, Monden Y (1991) Comparison of estrogen receptor and epidermal growth factor receptor content of primary and involved nodes in human breast cancer. Cancer 68:532–537
Wakeley CPG (1934) Massive diffuse hypertrophy of the breasts in girls: A report of four cases. Practitioner 132:608–613
Hazama H, Hori T, Nozawa H, Bando M (1981) Virginal hypertrophy of the right breast in a 12-year-old female: A case report of plastic correction with silicone bag prosthesis (English abstract). Jpn J Pediatr Surg 13:1543–1549
Boyce SW, Hoffman PGJ, Mathes SJ (1984) Recurrent macromastia after subcutaneous mastectomy. Ann Plast Surg 13:511–518
Wolner-Hanssen P, Palmer B, Sjoberg NO, Asted B (1981) Case report — Gigantomastia. Acta Obstet Gynecol Scand 60:525–527
Wise RJ (1976) Treatment of breast hypertrophy. Clin Plast Surg 3:289–300
Ryan RF, Pernoll ML (1985) Virginal hypertrophy. Plast Reconstr Surg 75:737–742
Furnas DW (1982) Subcutaneous mastectomy for juvenile hypertrophy of the breast: Report of a case. Br J Plast Surg 35:367–370
Gurgan JJ, Goldwyn RM (1987) Gigantomastia complicating pregnancy. Plast Reconst Surg 80:121–124
Castro CC (1977) Subcutaneous mastectomy for gigantomastia in an adolescent girl. Plast Reconstr Surg 59:575–578
Samuelov R, Siplovich L (1988) Juvenile gigantomastia. J Pediatr Surg 23:1014–1015
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Morimoto, T., Komaki, K., Mori, T. et al. Juvenile gigantomastia: Report of a case. Surg Today 23, 260–264 (1993). https://doi.org/10.1007/BF00309238
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DOI: https://doi.org/10.1007/BF00309238