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Macronodular adrenal hyperplasia causing Cushing's syndrome: Report of two cases and an overview

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Abstract

Of the various entities producing adrenal hyperfunction, nodular adrenal hyperplasia is rarely described, however, recent reports have established it as a distinct cause of Cushing's syndrome. Although the etiology of this disease remains uncertain, two distinct forms are recognised, namely: macronodular hyperplasia and micronodular dysplasia. Establishing the diagnosis preoperatively is difficult but essential to ensure the correct treatment is performed. Two cases of macronodular hyperplasia are reported herein followed by a review of the available literature on this subject.

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References

  1. Larsen JL, Cathey WJ, Odell WD (1986) Primary adrenocortical nodular dysplasia, a distinct subtype of Cushing's syndrome. Case report and review of the literature. Am J Med 80:976–984

    Google Scholar 

  2. Aron DC, Findling JW, Fitzgerald PA, Brooks RM, Fisher FF, Forsham PH, Tyrrell JB (1981) Pituitary ACTH dependency of nodular adrenal hyperplasia in Cushing's syndrome. Report of two cases and review of literarture. Am J Med 71:302–306

    Google Scholar 

  3. Chute AL, Robinson GC, Donhue WL (1949) Cushing's syndrome in children. J Pediat 34:20–39

    Google Scholar 

  4. Kirchner MA and Powell RD Jr (1964) Cushing's syndrome. Nodular cortical hyperplasia of adrenal glands with clinical and pathological features suggesting adrenocortical tumor. J Clin Endocrinol Metab 24:947–955

    Google Scholar 

  5. Meador CK, Bowdoin Owen WC Jr, Framer TA Jr (1967) Primary adrenocortical nodular dysplasia: A rare cause of Cushing's syndrome. J Clin Endocrinol Metab 27:1255–1263

    Google Scholar 

  6. Joffe SN, Brown C (1983) Nodular adrenal hyperplasia and Cushing's syndrome. Surgery 94:919–925

    Google Scholar 

  7. Neville AM, Symington T (1967) The pathology of the adrenal gland in Cushing's syndrome. J Pathol Bacteriol 93:19–25

    Google Scholar 

  8. May PB, Sobel H, Schneider G, Ertel N (1983) Nodular adrenal hyperplasia and elevated ACTH levels. Arch Int Med 143:136–140

    Google Scholar 

  9. Bondy PK (1985) Disorders of the adrenal cortex. In: Wilson JD, Foster DW (eds) Williams text-book of endocrinology, Saunders, Philadelphia, pp 411–413

    Google Scholar 

  10. Anonymous (1988) Nodular hyperplasia and Cushing's syndrome. Lancet II (8608):434 (editorial)

  11. Wulfratt NM, Drexhage HA, Wiersinga WM, Van der Gaag RD, Jeucken P, Mol JA (1988) Immunoglobulins of patients with Cushing's syndrome due to pigmented adrenocortical micronodular dysplasia stimulate in vitro steroidogenesis. J Clin Endocrinol Metab 66:301–307

    Google Scholar 

  12. Van Berkhout FT, Croughs RJM, Kater L (1986) Familial Cushing's syndrome due to nodular adrenocortical dysplasia: A putative receptor — antibody disease? Clin Endocrinol (Oxf) 24:299–310

    Google Scholar 

  13. Carney JA, Gordon H, Carpenter P, Shenoy BV, Go VL (1985) The complex of myxomas, spotty pigmentation and endocrine over activity. Medicine (Baltimore) 64:270–283

    Google Scholar 

  14. Danoff A, Jormark S, Lorber D, Fleischer N (1987) Adrenocortical micronodular dysplasia, cardiac myxomas, lentigines and spindle cell tumors. Arch Int Med 147:443–448

    Google Scholar 

  15. Ruder HJ, Loriaux DL, Lipsett MB (1974) Severe osteopenia in young adults associated with Cushing's syndrome due to micronodular adrenal disease. J Clin Endocrinol Metab 39:1138–1147

    Google Scholar 

  16. Cugini P, Letzia C, Di Palma L, Scavo D (1987) Primary adrenocortical nodular dysplasia a distinct subtype of Cushing's syndrome (letter). Am J Med 82:189–190

    Google Scholar 

  17. Schweizer-Cagianut M, Proesch ER, Hedlinger C (1980) Familial Cushing's syndrome with pituitary adrenocortical microadenomatosis (primary adrenocortical nodular dysplasia). Acta Endocrinol 94:529–535

    Google Scholar 

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Gupta, S., Chopra, P., Sikora, S. et al. Macronodular adrenal hyperplasia causing Cushing's syndrome: Report of two cases and an overview. Surg Today 22, 456–460 (1992). https://doi.org/10.1007/BF00308798

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  • DOI: https://doi.org/10.1007/BF00308798

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