Summary
The liver enzymes responsible for the breakdown and synthesis of glycogen from glucose have been investigated cytochemically in rats exposed to 1200 rads of x-irradiation. It was found that significant changes occur in their activities and that amylophosphorylase and amylo-1,6-glucosidase (debranching enzyme), both of which are responsible for the conversion of glycogen to glucose, are markedly inhibited by radiation. A significant inhibition of the activity of 1,4→1,6 transglucosidase (branching enzyme) was also observed. In contrast, the activity of UDPG-glycogen transglucosylase, which is responsible for the in vivo synthesis of 1,4-polysaccharides, was found to be stimulated.
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Catravas, G.N., McHale, C.G. A histochemical study of liver enzymes involved in glycogen metabolism in the X-irradiated rat. Histochemie 25, 247–255 (1971). https://doi.org/10.1007/BF00305943
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DOI: https://doi.org/10.1007/BF00305943