Regular Paper

Acta Neuropathologica

, Volume 90, Issue 3, pp 266-272

Endothelial lipopigment as an indicator of α-tocopherol deficiency in two equine neurodegenerative diseases

  • J. F. CummingsAffiliated withDepartment of Anatomy, College of Veterinary Medicine, Cornell University
  • , A. de LahuntaAffiliated withDepartment of Anatomy, College of Veterinary Medicine, Cornell University
  • , H. O. MohammedAffiliated withDepartment of Clinical Science, College of Veterinary Medicine, Cornell University
  • , T. J. DiversAffiliated withDepartment of Clinical Science, College of Veterinary Medicine, Cornell University
  • , B. A. SummersAffiliated withDepartment of Pathology, College of Veterinary Medicine, Cornell University
  • , B. A. ValentineAffiliated withDepartment of Pathology, College of Veterinary Medicine, Cornell University
  • , C. A. JacksonAffiliated withDepartment of Clinical Science, College of Veterinary Medicine, Cornell University

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Abstract

Two spontaneous neurodegenerative diseases of the horse, equine motor neuron disease (EMND) and equine degenerative myeloencephalopathy (EDM), have been associated with α-tocopherol deficiency, and both were characterized by prominent accumulations of endothelial lipopigment in the small vessels of the spinal cord. These endothelial pigment deposits appear to be reversible. In EMND horses pasture-supplemented for 9 months or more after the progression of weakness and wasting had arrested, there was very little endothelial lipopigment. The origin and the potential effects of these endothelial lipopigment accumulations are discussed.

Key words

Central nervous system endothelial lipopigment Equine motor neuron disease Equine degenerative myeloencephalopathy Vitamin E deficiency