Original Articles Ifosfamide, Renal Function, Mesna

Cancer Chemotherapy and Pharmacology

, Volume 23, Issue 5, pp 329-330

Severe renal failure following high-dose ifosfamide and mesna

  • Pax H. B. WillemseAffiliated withDepartment of Internal Medicine, Division of Medical Oncology, University Hospital
  • , Paul E. de JongAffiliated withDepartment of Nephrology, University Hospital
  • , Job B. ElemaAffiliated withDepartment of Pathology, University Hospital
  • , Nanno H. MulderAffiliated withDepartment of Internal Medicine, Division of Medical Oncology, University Hospital

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Summary

A 62-year-old woman developed subacute renal failure after the repeated administration of ifosfamide (IFX), despite its combination with continuous sodium 2-mercaptoethane sulfonate (mesna) infusion. Biopsy findings, the possible underlying mechanism, and the existing literature are discussed.