, Volume 23, Issue 5, pp 329-330

Severe renal failure following high-dose ifosfamide and mesna

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A 62-year-old woman developed subacute renal failure after the repeated administration of ifosfamide (IFX), despite its combination with continuous sodium 2-mercaptoethane sulfonate (mesna) infusion. Biopsy findings, the possible underlying mechanism, and the existing literature are discussed.