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Severe renal failure following high-dose ifosfamide and mesna

  • Original Articles
  • Ifosfamide, Renal Function, Mesna
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Summary

A 62-year-old woman developed subacute renal failure after the repeated administration of ifosfamide (IFX), despite its combination with continuous sodium 2-mercaptoethane sulfonate (mesna) infusion. Biopsy findings, the possible underlying mechanism, and the existing literature are discussed.

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Medical Oncology, University Hospital, Groningen, The Netherlands

    Pax H. B. Willemse & Nanno H. Mulder

  2. Department of Nephrology, University Hospital, Groningen, The Netherlands

    Paul E. de Jong

  3. Department of Pathology, University Hospital, Groningen, The Netherlands

    Job B. Elema

Authors
  1. Pax H. B. Willemse
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  2. Paul E. de Jong
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  3. Job B. Elema
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  4. Nanno H. Mulder
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Willemse, P.H.B., de Jong, P.E., Elema, J.B. et al. Severe renal failure following high-dose ifosfamide and mesna. Cancer Chemother. Pharmacol. 23, 329–330 (1989). https://doi.org/10.1007/BF00292414

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  • DOI: https://doi.org/10.1007/BF00292414

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