Human Genetics

, Volume 75, Issue 4, pp 378–380

X-linked hypohidrotic ectodermal dysplasia: DNA probe linkage analysis and gene localization

Authors

  • A. Clarke
    • Section of Medical GeneticsUniversity of Wales College of Medicine
  • M. Sarfarazi
    • Section of Medical GeneticsUniversity of Wales College of Medicine
  • N. S. T. Thomas
    • Section of Medical GeneticsUniversity of Wales College of Medicine
  • K. Roberts
    • Section of Medical GeneticsUniversity of Wales College of Medicine
  • P. S. Harper
    • Section of Medical GeneticsUniversity of Wales College of Medicine
Original Investigations

DOI: 10.1007/BF00284112

Cite this article as:
Clarke, A., Sarfarazi, M., Thomas, N.S.T. et al. Hum Genet (1987) 75: 378. doi:10.1007/BF00284112

Summary

A linkage study of 24 families with hypohidrotic (anhidrotic) ectodermal dysplasia (HED) has been performed. The previously suggested linkage to DXYS1 has been confirmed, and linkage to probes DXS14 and DXS3 has been established. We suggest that the HED locus lies in the centromeric region between DXYS1 on the long arm and DXS14 on the short arm of the X chromosome, probably on proximal Xq.

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Copyright information

© Springer-Verlag 1987