Abstract
The equations used in formulating the continuous model of granulocyte kinetics developed by O'Fallon et al. (1971) were analyzed to see if they could be altered to simulate a feedback mechanism operating on the production and development of granulocytes. After extensive study and modification of the continuous model, it was found that a discrete model based on a Leslie matrix procedure was more effective for simulating the feedback system. This discrete model was used to show experimentally, from a mathematical view point, that a feedback mechanism of some kind must be operating on the production and development of granulocytes. Further, the discrete model was subjected to preliminary tests (simultaneous and cascading feedback) to demonstrate that it has the capability of responding to feedback control.
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This work was completed while the first author was at North Carolina State University at Raleigh, Department of Statistics, Biomathematics Division, part of it under grant number 5T1 GM 678-15, National Institutes of Health, and part of it under grant number 5 F32 CA05964-02 from the National Cancer Institute
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McFarland, B.L., van der Vaart, H.R. A discrete mathematical model of unlabelled granulocyte kinetics. J. Math. Biology 22, 353–367 (1985). https://doi.org/10.1007/BF00276492
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DOI: https://doi.org/10.1007/BF00276492