Summary
Virulent mutants of phage Mu have been isolated after mutagenesis. The virulent phenotype results from most probably 2 mutations located in the c-A region of the Mu genome.
Vir mutants are trans-dominant; they induce the resident prophage upon infection in broth of any Mu lysogen. They however form plaques only on certain lysogens, that are monolysogenic for a mutant prophage. We further isolated secondary mutations in Mu Vir which suppress the virulent phenotype.
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Communicated by W. Arber
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van Vliet, F., Couturier, M., Desmet, L. et al. Virulent mutants of temperate phage Mu-1. Molec. Gen. Genet. 160, 195–202 (1978). https://doi.org/10.1007/BF00267481
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DOI: https://doi.org/10.1007/BF00267481