European Journal of Nuclear Medicine

, Volume 3, Issue 2, pp 87-89

First online:


A contribution to the study of its structure
  • Ugo FondaAffiliated withThe Isotope-Pharmacy
  • , Bente PedersenAffiliated withThe Isotope-Pharmacy

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Sephadex column chromatography has shown that 99mTc-diethyl-HIDA consists of two clearly separable components. One of them seems to be an intermediate compound changing into the other, almost completely within two hours after reconstitution of the diethyl-HIDA (Solco HIDA) with pertechnetate. The two components could be the mono- and biscomplex of N-(2,6-diethyl-acetanilid)-imino diacetic acid with one atom of technetium. Animal experiments show that there is no important difference in the biological distribution in mice between the two components.