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Comparative scanning of thyroid nodules with technetium-99m pertechnetate and technetium-99m methoxyisobutylisonitrile

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Abstract

Thyroid imaging was performed using technetium-99m methoxyisobutylisonitrile and technetium-99m pertechnetate in 58 patients. The 99mTc-pertechnetate scans showed a total of 77 nodules: 60 cold, 13 hot and 4 of normal activity. There was no 99mTc-MIBI accumulation in 46.4% of 99mTc-pertechnetate cold nodules; 27 (45%) of these nodules showed 99mTc-MIBI uptake with the same intensity as the surrounding normal tissue, and five (8.6%) became hot with 99mTc-MIBI. Of the 99mTc-pertechnetate hot nodules 11 (84.6%) could not be differentiated from the normal extranodular tissue on the 99mTc-MIBI scan. The histopathology of 34 surgically removed nodules proved that increased, normal or decreased 99mTc-MIBI accumulation is not specific for thyroid malignancy and that the 99mTc-MIBI uptake depends mainly on the viability of thyroid tissue.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Central Hospital of the Ministry of the Interior, 1071 Városligeti fasor 9-11, Budapest, Hungary

    Iván Földes & Annamária Lévay

  2. Department of Pathology, Central Hospital of the Ministry of the Interior, 1071 Városligeti fasor 9-11, Budapest, Hungary

    Gyula Stotz

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  1. Iván Földes
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  2. Annamária Lévay
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  3. Gyula Stotz
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Correspondence to: I. Földes

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Földes, I., Lévay, A. & Stotz, G. Comparative scanning of thyroid nodules with technetium-99m pertechnetate and technetium-99m methoxyisobutylisonitrile. Eur J Nucl Med 20, 330–333 (1993). https://doi.org/10.1007/BF00169809

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  • DOI: https://doi.org/10.1007/BF00169809

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