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T1 and T2 Proton Nuclear Magnetic Resonance (N.M.R.) relaxation times in vitro and human intracranial tumours

Results from 98 patients

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Summary

137 samples of intracranial tumours have been studied in proton NMR spectroscopy. T1 and T2 relaxation times are above those of normal grey and white matter. Differential diagnosis between benign and malignant brain tumours does not seem feasible upon proton T1 and T2 alone. Histological correlations allowed us to specify secondary changes accounting for T1 and T2 variations (oedema, microcyst, stroma reaction, necrosis).

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References

  1. Margulis RA, Higgins CB, Kaufman L, Crooks LE: Clinical Magnetic Resonance Imaging. Radiology Research and Education Foundation. San Francisco, 1983.

    Google Scholar 

  2. Holland GN, Hawkes RC, Moore WS: Nuclear Magnetic Resonance tomography of the brain: coronal and sagittal sections. J Comput Assist Tomogr 4:429–433, 1980.

    Google Scholar 

  3. Hawkes RC, Holland GN, Moore WS, Worthington BS: Nuclear Magnetic Resonance tomography of the brain: a preliminary clinical assessment with demonstration of pathology. J Comput Assist Tomogr 4:577–586, 1980.

    Google Scholar 

  4. Doyle FH, Gore JC, Pennok JM, Bydder GM, Orr JS, Steiner RE: Imaging of the Brain by Nuclear Magnetic Resonance. Lancet 2:53–57, 1981.

    Google Scholar 

  5. Grafin von Einsiedel H, Loffler W: Nuclear Magnetic Resonance Imaging of Brain Tumours unrevealed by CT*. Europ J Radiol 3:(2), 226–234.

  6. Bydder GM, Steiner RE: Nuclear Magnetic Resonance Imaging of the Brain. Neuroradiology 23:231–240, 1982.

    Google Scholar 

  7. Bydder GM, Steiner RE, Young IR: Clinical NMR Imaging of the brain: 140 cases. Am J of Radiology 139:215–236, 1982.

    Google Scholar 

  8. Brady TJ, Buonanno FS, Pykett IL, New PFJ, Davis KR, Pohost GM, Kistler JP: Preliminary clinical results of 1H imaging of cranial neoplasms: in vivo measurements of T1 and — mobile protondensity. AJNR 4:225–228, 1983.

    Google Scholar 

  9. Hawkes RC, Holland GN, Moore WS, Kean DM, Worthington BS: NMR tissue characterization in intracranial tumors: preliminary results. AJNR 4:830–832, 1983.

    Google Scholar 

  10. Brant-Zawadzki M, Badami JP, Mills CM, Norman D, Newton TH: Primary intracranial tumor imaging: a comparison of magnetic resonance with CT. Radiology 150:435–440, 1984.

    Google Scholar 

  11. Benoist L, Chatel M, Menault F, de Certaines J: Variations des temps de relaxation du proton dans des tumeurs humaines intra-craniennes. Premiers résultats. J Biophys et Med Nucl 5:(3),143–146, 1981.

    Google Scholar 

  12. De Certaines JD: Specific and non-specific proton relaxation times variations in cancer, In: Jaklovsky J (ed): Nuclear Magnetic Resonance Imaging: Future Potential. New England Nuclear company, Boston Massachussetts, 1984. Chap. V (To be published).

    Google Scholar 

  13. Go KG, Edzes HT: Water in brain edema. Arch Neurol 32:462–465, 1975.

    Google Scholar 

  14. Naruse S, Horikawa Y, Tanaka C, Hirakawa W, Nishikawa H, Yoshizaki K: Proton Nuclear Magnetic Resonance studies on brain edema. J Neurosurg 56:(6),747–752, 1982.

    Google Scholar 

  15. Benoist L, Allain H, Linée Ph, Hermon MC, Le Polles M, de Certaines J: Intéret de la RMN du proton dans l'étude pharmacologique de l'oedeme cérébral. J de Pharmacologie 15:(2),143–156, 1984.

    Google Scholar 

  16. De Certaines J, Gallier J, Lancien G, Bellossi A: NMR study of experimental lewis lung carcinoma. J of Clinical Hematology and Oncology 9:(3),255–264, 1979.

    Google Scholar 

  17. Ling CR, Foster MA: Changes in NMR relaxation time associated with local inflammatory response. Phys Med Biol 27:6,853–860, 1982.

    Google Scholar 

  18. Beall PT, Hazlewood CF, Rao PN: Cell-cycle phase specific changes in the NMR patterns in synchronized Hela cells. J Cell Biology 67:23A, 1975.

    Google Scholar 

  19. Beall PT, Cailleau RM, Hazlewood CF: Doubling time and the NMR properties of water in human breast cancer cell lines. In Vitro 13:3,204, 1977.

    Google Scholar 

  20. Beall PT, Hazlewood CF, Rao PN: NMR patterns of intracellular water as a function of Hela cell cycle. Science 192:904–907, 1976.

    Google Scholar 

  21. Lebas JF, Leviel JL, Lecorps M, Benabid AL: N.M.R. relaxation times and C.T. attenuation numbers in Human Brain Tumours. A correlation study from serial stereotactic biopsy. J Comput Assist Tomogr (á paraître).

  22. Fung BM, Wei SC: The effect of alkali and alkaline earth salts on the structure of hydrated collagen fibers as studied by deuterium N.M.R. Biopolymers 12:1053–1062, 1973.

    Google Scholar 

  23. Lejeune JJ, Gallier J, Rivet P, De Certaines JD: Is an interpretation model for proton relaxation times in biological tissue possible? Magnetic resonance in medicine 1:(2)192, 1984.

    Google Scholar 

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Chatell, M., Darcel, F., de Certaines, J. et al. T1 and T2 Proton Nuclear Magnetic Resonance (N.M.R.) relaxation times in vitro and human intracranial tumours. J Neuro-Oncol 3, 315–321 (1986). https://doi.org/10.1007/BF00165579

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  • DOI: https://doi.org/10.1007/BF00165579

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