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Screening of melanin biosynthesis inhibitors from marine microalgae using Streptomyces bikiniensis bioassay

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Biotechnology Techniques

Summary

Inhibitors of melanin biosynthesis from marine microalgae were screened against a melanin-producing microorganism, Streptomyces bikiniensis. From 28 marine microalgal strains, 5 were found showing inhibitory activity. Of these, the extracts (50μl, 2μg total organic carbon/μl) from two marine green algae showed strongly inhibited melanin biosynthesis, but showed less than 30 % inhibitory activity against mushroom tyrosinase.

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Authors and Affiliations

  1. Department of Biotechnology, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei-shi, 184, Tokyo, Japan

    Yoji Wachi, Koji Sode, Kenichi Horikoshi, Haruko Takeyama & Tadashi Matsunaga

  2. Safety and Analytical Research Center, Shiseido Research Center, Yokohama, 223, Kawasaki, Japan

    Yoji Wachi

Authors
  1. Yoji Wachi
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  2. Koji Sode
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  3. Kenichi Horikoshi
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  4. Haruko Takeyama
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  5. Tadashi Matsunaga
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Wachi, Y., Sode, K., Horikoshi, K. et al. Screening of melanin biosynthesis inhibitors from marine microalgae using Streptomyces bikiniensis bioassay. Biotechnol Tech 9, 633–636 (1995). https://doi.org/10.1007/BF00156347

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  • DOI: https://doi.org/10.1007/BF00156347

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