Ischemia–Reperfusion Injury of the Liver with Special Reference to Calcium-Dependent Mechanisms
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- Sakon, M., Ariyoshi, H., Umeshita, K. et al. Surg Today (2002) 32: 1. doi:10.1007/s595-002-8105-8
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Ischemia–reperfusion (I/R) injury is a complex process involving numerous intracellular signaling pathways, mediators, cells, and pathophysiological disturbances; its prevention during liver surgery is of utmost importance. In this review, we divide hepatic I/R injury into two phases, intracellular and extracellular, for a better understanding of the processes involved. Ca2+ and Ca2+-dependent reactions play an important role as a trigger in the former phase, while the subsequent generation of bioactive substances plays a predominant role in the latter phase. These findings indicate that a combination of different therapeutic approaches against Ca2+-dependent steps may help prevent I/R injury of the liver.