Surgery Today

, Volume 32, Issue 1, pp 1–12

Ischemia–Reperfusion Injury of the Liver with Special Reference to Calcium-Dependent Mechanisms

Authors

  • Masato Sakon
    • Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
  • Hideo Ariyoshi
    • Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
  • Koji Umeshita
    • Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
  • Morito Monden
    • Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
Review Article

DOI: 10.1007/s595-002-8105-8

Cite this article as:
Sakon, M., Ariyoshi, H., Umeshita, K. et al. Surg Today (2002) 32: 1. doi:10.1007/s595-002-8105-8

Abstract

Ischemia–reperfusion (I/R) injury is a complex process involving numerous intracellular signaling pathways, mediators, cells, and pathophysiological disturbances; its prevention during liver surgery is of utmost importance. In this review, we divide hepatic I/R injury into two phases, intracellular and extracellular, for a better understanding of the processes involved. Ca2+ and Ca2+-dependent reactions play an important role as a trigger in the former phase, while the subsequent generation of bioactive substances plays a predominant role in the latter phase. These findings indicate that a combination of different therapeutic approaches against Ca2+-dependent steps may help prevent I/R injury of the liver.

Key words IschemiareperfusionCell deathLiver

Copyright information

© Springer-Verlag 2002