Journal of Nephrology

, Volume 27, Issue 5, pp 529–536

Effects of Italian Mediterranean organic diet vs. low-protein diet in nephropathic patients according to MTHFR genotypes

  • Nicola Di Daniele
  • Laura Di Renzo
  • Annalisa Noce
  • Leonardo Iacopino
  • Pietro Manuel Ferraro
  • Mariagiovanna Rizzo
  • Francesca Sarlo
  • Emidio Domino
  • Antonino De Lorenzo
Original Article

DOI: 10.1007/s40620-014-0067-y

Cite this article as:
Di Daniele, N., Di Renzo, L., Noce, A. et al. J Nephrol (2014) 27: 529. doi:10.1007/s40620-014-0067-y

Abstract

Background

Several reports associate an Italian-style Mediterranean diet (IMD) with lower risk of cardiovascular disease and morbidity. The present study aimed to explore the effects of an Italian Mediterranean organic diet (IMOD) versus low-protein diet (LPD) in chronic kidney disease (CKD) patients, according to patients’ carrier status for the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism.

Methods

A total of 40 male patients with CKD and stable renal function (Kidney Disease Outcomes Quality Initiative stages 2 and 3) were classified according to MTHFR polymorphism as carrier T(+) or non carrier T(−). At the time of enrolment (T0) patients’ diet consisted of LPD; they were then administered IMD for 14 days (T1), thereupon IMOD for 14 days (T2). Patients underwent a complete medical history, body composition assessment and biochemical analysis.

Results

Baseline homocysteine levels were on average 8.24 mol/l higher (95 % confidence interval 6.47, 10.00) among T(+) than T(−) and the difference was statistically significant (p < 0.001). We found a significant interaction between MTHFR status and the effect of both the IMD and IMOD on homocysteine levels compared to LPD (p for interaction <0.001). Both the IMD and IMOD resulted in significant variations of anthropometric and laboratory measurements.

Conclusions

IMD and IMOD diets could represent a viable alternative to LPD in CKD patients on conservative therapy. The effect of these diets seems to be influenced by MTHFR genotypes.

Keywords

Body composition Cardiovascular disease risk Chronic kidney disease C677T MTHFR polymorphism Italian Mediterranean organic diet 

Copyright information

© Italian Society of Nephrology 2014

Authors and Affiliations

  • Nicola Di Daniele
    • 1
  • Laura Di Renzo
    • 2
    • 3
  • Annalisa Noce
    • 1
  • Leonardo Iacopino
    • 2
  • Pietro Manuel Ferraro
    • 4
  • Mariagiovanna Rizzo
    • 2
  • Francesca Sarlo
    • 2
  • Emidio Domino
    • 2
  • Antonino De Lorenzo
    • 2
    • 3
  1. 1.Department of Systems Medicine, Hypertension and Nephrology UnitUniversity of “Tor Vergata”RomeItaly
  2. 2.Division of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and PreventionUniversity of “Tor Vergata”RomeItaly
  3. 3.I.N.Di.M, National Institute for Mediterranean Diet and NutrigenomicsAmanteaItaly
  4. 4.Division of Nephrology-Renal Program, Department of Medical SciencesCatholic University of the Sacred HeartRomeItaly

Personalised recommendations