Aging Clinical and Experimental Research

, Volume 26, Issue 6, pp 583–589

The relationship of sex hormone-binding globulin (SHBG) gene polymorphisms with serum SHBG level and metabolic syndrome in Chinese Han males

Authors

  • Xiao-Na Pang
    • Department of GeriatricsZhongshan Hospital, Fudan University
  • Ying Yuan
    • Department of GeriatricsZhongshan Hospital, Fudan University
  • Yan Sun
    • Department of GeriatricsZhongshan Hospital, Fudan University
  • Ji-Ping Shen
    • Department of GeriatricsZhongshan Hospital, Fudan University
  • Xiao-Yun Zha
    • Department of GeriatricsZhongshan Hospital, Fudan University
    • Department of GeriatricsZhongshan Hospital, Fudan University
Original Article

DOI: 10.1007/s40520-014-0215-1

Cite this article as:
Pang, X., Yuan, Y., Sun, Y. et al. Aging Clin Exp Res (2014) 26: 583. doi:10.1007/s40520-014-0215-1

Abstract

Objective

Epidemiological studies have shown that circulating sex hormone-binding globulin (SHBG) levels are lower in metabolic syndrome (MetS) patients than in non-MetS individuals. In this study, we investigated the relationship of polymorphisms in the SHBG gene with the serum SHBG levels and MetS in Han Chinese.

Methods

We performed a cross-sectional study of 316 subjects who were recruited from a health checkup population at Zhongshan Hospital, Fudan University. Anthropometric measurements, blood pressure, fasting plasma glucose, lipid levels, total testosterone, and SHBG levels were obtained in addition to the seven SHBG single-nucleotide polymorphisms (SNPs).

Results

The variant allele (AG or AA) carriers in rs6259, compared to the wild-type allele carriers (GG), have a lower risk for MetS [OR 0.56, 95 % confidence interval (CI) 0.33–0.96] and higher serum SHBG and TT levels (P = 0.016, 0.004). CT or TT allele carriers in rs3760213, compared to CC allele carriers, also have a lower risk for MetS (OR 0.59, 95 % CI 0.34–1.00) and significantly higher SHBG and TT levels (P = 0.029, 0.009). Carriers having both of the variant alleles had the lowest risk of MetS (OR 0.51, 95 % CI 0.275–0.950) and the highest SHBG levels. The risk of MetS rose with the decrease in serum SHBG levels for rs6259 and rs376021 carriers.

Conclusion

rs6259 and rs3760213 SNPs are associated with the risk of MetS and lower serum SHBG level in Chinese Han males.

Keywords

Metabolic syndromeSex hormone-binding globulinPolymorphismMale

Copyright information

© Springer International Publishing Switzerland 2014