Original Article

Aging Clinical and Experimental Research

, Volume 26, Issue 2, pp 193-199

Serum cystatin C and indices of lung function in elderly Chinese men with chronic obstructive pulmonary disease

  • Meng ZhangAffiliated withCardiology Division, Fu Wai Hospital and Cardiovascular Institute, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College
  • , Shu-Hong FuAffiliated withClinical Department of Geriatrics, Chinese PLA General Hospital
  • , Hua CuiAffiliated withSecond Geriatric Cardiology Division, Department of Geriatrics, Chinese PLA General Hospital Email author 
  • , Bing-Po ZhuAffiliated withFirst Geriatric Cardiology Division, Chinese PLA General Hospital
  • , Lin LiuAffiliated withClinical Department of Geriatrics, Chinese PLA General Hospital
  • , De-Long WangAffiliated withClinical Department of Geriatrics, Chinese PLA General Hospital

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Abstract

Objective

The aim of this cross-sectional case–control study was to determine the relationship between serum cystatin C (sCysC) levels and lung function in elderly male patients with chronic obstructive pulmonary disease (COPD).

Methods

This study included 251 Chinese men (age ≥ 65 years) who were divided into COPD (n = 129) and non-COPD (n = 122) groups. Participants underwent lung function and laboratory testing, including measurement of sCysC levels. Relationships between sCysC concentration and indices of lung function were assessed by multiple regression analysis.

Results

Participants in the COPD group displayed higher sCysC concentrations (P = 0.041) and lower lung function (P < 0.001) compared to participants in the non-COPD group. Multiple linear regression analyses revealed that the reciprocal of the sCysC concentration (1/sCysC) was positively associated with the predicted forced expiratory volume in 1 s in all subjects (β = 0.156, P = 0.009). The findings indicate that high sCysC levels were directly associated with decreased lung function in elderly Chinese men with COPD.

Conclusions

High sCysC concentration may be a potential indicator of impaired lung function, and its application may improve the diagnosis and assessment of COPD severity in elderly male patients.

Keywords

Cystatin C Chronic obstructive pulmonary disease Lung function Elderly patient